{"created":"2023-06-20T16:47:13.017505+00:00","id":18856,"links":{},"metadata":{"_buckets":{"deposit":"d3cb56f5-763c-4771-92d1-dd8b8ac827b4"},"_deposit":{"created_by":3,"id":"18856","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18856"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018856","sets":["14:2667:4374"]},"author_link":["31909","3267","32204"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：網膜組織においては網膜色素上皮がEMT研究の主要な細胞としてよく検討が行われ、知見が集積されてきている。しかしながらuPARなどの線溶系を介した網膜組織でのEMT誘導についてはこれまであまり報告がなく、uPAR強制発現細胞（ARPE-19）を作成して検討を行った。結果、uPAR単独の作用ではARPE-19細胞にEMT様変化は誘導できず、コラーゲンゲルの収縮能についてもゲル収縮促進作用はみられなかった。網膜でEMTは、uPAR発現亢進による単独刺激では誘導できず、TGF-βなどの成長因子やインターロイキンなどのサイトカインの関与も、今後検討を加える必要があると考えられた。\n研究成果の概要（英文）：In EMT (epithelial-messenchymal transition) study, retinal pigment epithelial cells have been the main research subject and findings of EMT on retinal pigment epithelial cells have been accumulated. Contrarily, there are few reports, so far, on EMT induced by uPAR through the fibrinolytic system. Therefore, in this study, uPAR was stably introduced into human retinal pigment epithelial cells (ARPE-19), and EMT induced by uPAR was investigated. In consequence, EMT-like changes could not be recognized in ARPE-10 by stably introduced uPAR alone, and collagen gel contraction could not be recognized, either. EMT could not be induced in the retina with a single stimulation of increased expression of uPAR. Involvement of growth factors like TGF-β and cytokines like interleukin should also be considered in the future study.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2015～2016;   課題番号：15K20294;   研究分野：眼科領域;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K20294/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究協力者/研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"AOMATSU, Keiichi"},{"subitem_text_language":"en","subitem_text_value":"SUGIOKA, Koji"},{"subitem_text_language":"en","subitem_text_value":"YOSHIDA, Koji"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学生物理工部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"青松, 圭一"},{"creatorName":"アオマツ, ケイイチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31909","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60411633","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"杉岡, 幸二"},{"creatorName":"スギオカ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3267","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"50399119","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"吉田, 浩二"},{"creatorName":"ヨシダ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"32204","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60230736","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"15K20294seika.pdf","filesize":[{"value":"215.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"15K20294seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18856/files/15K20294seika.pdf"},"version_id":"45a0cca7-91d5-4e18-a38d-99a521e83203"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"uPA","subitem_subject_scheme":"Other"},{"subitem_subject":"uPAR","subitem_subject_scheme":"Other"},{"subitem_subject":"ARPE-19","subitem_subject_scheme":"Other"},{"subitem_subject":"EMT","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ARPE-19におけるuPA/uPAR制御性EMTの検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ARPE-19におけるuPA/uPAR制御性EMTの検討"},{"subitem_title":"Investigation of uPA/uPAR induced EMT in ARPE-19","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18856","relation_version_is_last":true,"title":["ARPE-19におけるuPA/uPAR制御性EMTの検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:46:54.336308+00:00"}