{"created":"2023-06-20T16:47:12.790801+00:00","id":18851,"links":{},"metadata":{"_buckets":{"deposit":"aabc2a6b-2943-4d62-b8d5-8e2ea9492565"},"_deposit":{"created_by":3,"id":"18851","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18851"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018851","sets":["14:2667:4374"]},"author_link":["31892","31891","31893","31890"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：網膜において、光暴露によってもcFosの誘導が生じない、光入力がゲートされた位相の存在を確認した。さらに網膜神経節細胞のうちメラノプシンを含有する神経細胞（視交叉上核に投射する。）のみを観察し、cFosの発現に位相依存性があることが明らかになった。これは視交叉上核への光情報が網膜レベルで制御されていることを示唆する。また、マウスの明暗の日周変動をシフトさせ時差ぼけ状態を作り出し、ゲーティング位相のシフト様式を明らかにした。ゲートの位相シフト速度は視交叉上核背内側部（DMSCN）の概日リズムの位相シフトとよく一致した。この発見は、DMSCNがゲートの位相を決定することを示唆している。\n研究成果の概要（英文）：In the retina, using cFOS as a marker for neural excitation, we found dead zone in which cFos induction does not occur even by light exposure. Furthermore, there is a phase dependency in the cFos induction even in ganglion cells expressing melanopsin that were projected to the suprachiasmatic nucleus. This suggests that the optical information delivered to the suprachiasmatic nucleus is regulated at the retinal level. We also clarified the shift pattern of the phase of the gating in the SCN. The manner of the phase shift of the gate is well corresponded with the phase shift of the circadian rhythm in the dorsal part of the suprachiasmatic nucleus (DMSCN). This finding suggests that the circadian clock in the DMSCN determines the phase of the gate.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26460326;   研究分野：環境生理,時間生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460326/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SHIGEYOSHI, Yasufumi"},{"subitem_text_language":"en","subitem_text_value":"KOINUMA, Satoshi"},{"subitem_text_language":"en","subitem_text_value":"IKEGAMI, Keisuke"},{"subitem_text_language":"en","subitem_text_value":"SUJINO, Mitsugu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"重吉, 康史"},{"creatorName":"シゲヨシ, ヤスフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"鯉沼, 聡"},{"creatorName":"コイヌマ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"池上, 啓介"},{"creatorName":"イケガミ, ケイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"筋野, 貢"},{"creatorName":"スジノ, ミツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26460326seika.pdf","filesize":[{"value":"269.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26460326seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18851/files/26460326seika.pdf"},"version_id":"002ef089-5501-4d4c-81c7-4d36ba52a37b"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"視交叉上核","subitem_subject_scheme":"Other"},{"subitem_subject":"体内時計","subitem_subject_scheme":"Other"},{"subitem_subject":"概日リズム","subitem_subject_scheme":"Other"},{"subitem_subject":"日内リズム","subitem_subject_scheme":"Other"},{"subitem_subject":"日周リズム","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜","subitem_subject_scheme":"Other"},{"subitem_subject":"Gating","subitem_subject_scheme":"Other"},{"subitem_subject":"Dead zone","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"体内時計中枢ゲート機構の探求―位相特異的光照射情報遮断の仕組みに迫るー","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"体内時計中枢ゲート機構の探求―位相特異的光照射情報遮断の仕組みに迫るー"},{"subitem_title":"Exploration of gating against delivery of photic information to the mammalian central circadian clock","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18851","relation_version_is_last":true,"title":["体内時計中枢ゲート機構の探求―位相特異的光照射情報遮断の仕組みに迫るー"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:47:03.945182+00:00"}