{"created":"2023-06-20T16:47:12.700025+00:00","id":18849,"links":{},"metadata":{"_buckets":{"deposit":"b6cc9118-b660-42a3-b822-135a4bb194b8"},"_deposit":{"created_by":3,"id":"18849","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18849"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018849","sets":["14:2667:4374"]},"author_link":["31886"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：野生型マウスとklothoマウスではアディポネクチン遺伝子に発現に有意差を認めなかった。LPS誘導性TNF-α産生は分泌型α-klotho蛋白存在下では抑制されず、FGF23存在下に有意に増強した。FGF23はα-klotho蛋白の存在の有無にかかわらずTNF-α産生を促進するよう機能している可能性がある。klothoマウスでは、TNF-αの過剰産生が創傷治癒遷延に関与している可能性が考えられた。\n研究成果の概要（英文）：Expression of Adiponectin mRNA was not significantly different between wild type and klotho deficient mice. LPS-induced TNF-α production was not suppressed in the presence of Secreted α-klotho protein but was significantly increased in the presence of FGF23. Thus, FGF23 may have a function to promote TNF-α production independently of α-klotho protein. In klotho deficientl mice, excess production of TNF-α in wounds might cause delay in wound healing.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2013～2016;   課題番号：25861692;   研究分野：形成外科;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25861692/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YAMAUCHI, Makoto"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"山内, 誠"},{"creatorName":"ヤマウチ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"31886","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90438060","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"25861692seika.pdf","filesize":[{"value":"388.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25861692seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18849/files/25861692seika.pdf"},"version_id":"02a4f6ea-32c6-4397-89f1-e65242817d4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"老化","subitem_subject_scheme":"Other"},{"subitem_subject":"病理学","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"クロトー遺伝子が皮下脂肪織および皮膚創傷治癒に及ぼす影響について","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"クロトー遺伝子が皮下脂肪織および皮膚創傷治癒に及ぼす影響について"},{"subitem_title":"Effect of Klotho gene on subcutaneous fat tissue and skin wound healing","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18849","relation_version_is_last":true,"title":["クロトー遺伝子が皮下脂肪織および皮膚創傷治癒に及ぼす影響について"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:47:08.834150+00:00"}