{"created":"2023-06-20T16:47:12.654550+00:00","id":18848,"links":{},"metadata":{"_buckets":{"deposit":"9586cbbf-7de6-4d81-b7ab-2125595310f8"},"_deposit":{"created_by":3,"id":"18848","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18848"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018848","sets":["14:2667:4374"]},"author_link":["31884","31885"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：アルファ線核種であるラジウム-223（Ra-223）は骨に親和性を持っており、去勢抵抗性前立腺癌骨転移に対して全生存期間を延長する治療用放射性医薬品として医療に導入されつつある。本研究において、Ra-223の物理学的化学的特性を明らかにし、測定・計数や管理・汚染除去、撮像などの手法を確立するために、各種計測機器による光子の計数、汚染除去に関する実験、ガンマカメラによる撮像の検討を行った。GM計数管、NaI(Tl)シンチレーション計数管、ZnS(Ag)検出器の特性、汚染除去に関しては素材に付着したRa-223の早期の除去が重要であること、撮像にガンマ線・特性X線を用いることができることを示した。\n研究成果の概要（英文）：The alpha-emitter radium-223 (Ra-223), which has an affinity to the bone, has been introduced into clinical practices as a therapeutic radiopharmaceutical that prolongs overall survival in castration-resistant prostate cancer with bone metastases. In this study, we conducted studies on measurements of photons by various counting devices in order to clarify the physiochemical properties of Ra-223, on decontamination methods assuming contamination of materials, and also appropriate parameters for imaging by gamma camera. We demonstrated the characteristics of GM counters，Na(Tl) scintillation counters, and a ZnS(Ag) counter, the importance of early decontamination of materials, and feasibility of gamma rays and characteristic X rays for imaging.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2013～2016;   課題番号：25461854;   研究分野：放射線医学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461854/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HOSONO, Makoto"},{"subitem_text_language":"en","subitem_text_value":"HOHARA, Shinya"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 教授"},{"subitem_text_value":"近畿大学原子力研究所; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"細野, 眞"},{"creatorName":"ホソノ, マコト","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"芳原, 新也"},{"creatorName":"ホウハラ, シンヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"25461854seika.pdf","filesize":[{"value":"166.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25461854seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18848/files/25461854seika.pdf"},"version_id":"ff2ab397-f8cd-44bc-aa18-7a73bb00dd0f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ラジウム-223","subitem_subject_scheme":"Other"},{"subitem_subject":"radium-223","subitem_subject_scheme":"Other"},{"subitem_subject":"α線","subitem_subject_scheme":"Other"},{"subitem_subject":"放射線計測","subitem_subject_scheme":"Other"},{"subitem_subject":"線量評価","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"アルファ線放出核種ラジウム-223による骨転移治療の基礎的検討","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アルファ線放出核種ラジウム-223による骨転移治療の基礎的検討"},{"subitem_title":"Preliminary studies on therapy of bone metastases by alpha-emitter radium-223","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18848","relation_version_is_last":true,"title":["アルファ線放出核種ラジウム-223による骨転移治療の基礎的検討"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:47:10.924405+00:00"}