{"created":"2023-06-20T16:47:12.565550+00:00","id":18846,"links":{},"metadata":{"_buckets":{"deposit":"6a71fee6-57c0-4c84-8c0f-84c8bf451bcc"},"_deposit":{"created_by":3,"id":"18846","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18846"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018846","sets":["14:2667:4374"]},"author_link":["31879","31876","31880","31875","31878","31877"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）： CCL28遺伝子欠損マウスでは、大腸粘膜でのIgA産生細胞の減少と分布異常、糞便中のIgA量の著明な減少、および個々のIgA産生細胞のIgA産生量の低下が見いだされ、CCL28は大腸粘膜でのIgA産生に重要な役割を担っていることが確認された。さらにCCL28遺伝子欠損マウスの糞便ではバシラス綱が相対的に増加していた。大腸でのIgA産生量の低下と細菌叢の変化と関連して、CCL28遺伝子欠損マウスではデキストラン硫酸誘発腸炎の増悪が見られ、それは抗菌薬投与で軽減された。\n研究成果の概要（英文）： CCL28 is expressed in the mucosal tissues and to attract IgA-antibody secreting cells (IgA-ASCs) via CCR10. CCL28 has an antimicrobial activity against microbes in vitro. However, in vivo evidence for the role of CCL28 in the mucosal immunity remains scanty. We generated CCL28-deficient mice and demonstrated that CCL28-deficient mice showed reduced numbers and altered distribution of IgA-ASCs in the colon. The IgA contents in the fecal extracts were low. The average amounts of IgA secreted by a single IgA-ASC isolated from the lamina propria of the colon was reduced. Furthermore, the 16S rRNA sequencing analysis of feces revealed an increase of the Class Bacilli. Consistent with the low IgA production and altered microbiota in the colon, CCL28-deficient mice had aggravated colitis upon treatment with dextran sulfate, which was ameliorated by oral antibiotics. Therefore, CCL28 has an role in the mucosal immunity of the colon as a chemoattractant with a direct antimicrobial activity.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26460582;   研究分野：免疫学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460582/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者/研究分担者/連携研究者/研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YOSHIE, Osamu"},{"subitem_text_language":"en","subitem_text_value":"HIGUCHI, Tomonori"},{"subitem_text_language":"en","subitem_text_value":"KANAI, Kyosuke"},{"subitem_text_language":"en","subitem_text_value":"KANAI, Kyosuke"},{"subitem_text_language":"en","subitem_text_value":"NAKAYAMA,Takashi"},{"subitem_text_language":"en","subitem_text_value":"TSUNODA, Ikuo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"義江, 修"},{"creatorName":"ヨシエ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"樋口, 智紀"},{"creatorName":"ヒグチ, トモノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"金井, 亨輔"},{"creatorName":"カナイ, キョウスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"藤田, 貢"},{"creatorName":"フジタ, ミツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中山, 隆志"},{"creatorName":"ナカヤマ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"角田, 郁生"},{"creatorName":"ツノダ, イクオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26460582seika.pdf","filesize":[{"value":"193.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26460582seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18846/files/26460582seika.pdf"},"version_id":"304466b0-b488-4623-96a2-fb4794760990"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ケモカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"CCL28","subitem_subject_scheme":"Other"},{"subitem_subject":"腸管免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"IgA","subitem_subject_scheme":"Other"},{"subitem_subject":"腸内細菌叢","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"粘膜免疫におけるCCL28の役割の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"粘膜免疫におけるCCL28の役割の解明"},{"subitem_title":"Role of CCL28 for mucosal immunity","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18846","relation_version_is_last":true,"title":["粘膜免疫におけるCCL28の役割の解明"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:47:15.287695+00:00"}