@techreport{oai:kindai.repo.nii.ac.jp:00018846,
 author = {義江, 修 and 樋口, 智紀 and 金井, 亨輔 and 藤田, 貢 and 中山, 隆志 and 角田, 郁生},
 month = {},
 note = {研究成果の概要（和文）： CCL28遺伝子欠損マウスでは、大腸粘膜でのIgA産生細胞の減少と分布異常、糞便中のIgA量の著明な減少、および個々のIgA産生細胞のIgA産生量の低下が見いだされ、CCL28は大腸粘膜でのIgA産生に重要な役割を担っていることが確認された。さらにCCL28遺伝子欠損マウスの糞便ではバシラス綱が相対的に増加していた。大腸でのIgA産生量の低下と細菌叢の変化と関連して、CCL28遺伝子欠損マウスではデキストラン硫酸誘発腸炎の増悪が見られ、それは抗菌薬投与で軽減された。
研究成果の概要（英文）： CCL28 is expressed in the mucosal tissues and to attract IgA-antibody secreting cells (IgA-ASCs) via CCR10. CCL28 has an antimicrobial activity against microbes in vitro. However, in vivo evidence for the role of CCL28 in the mucosal immunity remains scanty. We generated CCL28-deficient mice and demonstrated that CCL28-deficient mice showed reduced numbers and altered distribution of IgA-ASCs in the colon. The IgA contents in the fecal extracts were low. The average amounts of IgA secreted by a single IgA-ASC isolated from the lamina propria of the colon was reduced. Furthermore, the 16S rRNA sequencing analysis of feces revealed an increase of the Class Bacilli. Consistent with the low IgA production and altered microbiota in the colon, CCL28-deficient mice had aggravated colitis upon treatment with dextran sulfate, which was ameliorated by oral antibiotics. Therefore, CCL28 has an role in the mucosal immunity of the colon as a chemoattractant with a direct antimicrobial activity., 研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26460582;   研究分野：免疫学;   科研費の分科・細目：, application/pdf},
 title = {粘膜免疫におけるCCL28の役割の解明},
 year = {2017},
 yomi = {ヨシエ, オサム and ヒグチ, トモノリ and カナイ, キョウスケ and フジタ, ミツグ and ナカヤマ, タカシ and ツノダ, イクオ}
}