{"created":"2023-06-20T16:47:12.427967+00:00","id":18843,"links":{},"metadata":{"_buckets":{"deposit":"6eff7928-25de-4e70-b7ef-e08634aeb04a"},"_deposit":{"created_by":3,"id":"18843","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18843"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018843","sets":["14:2667:4374"]},"author_link":["31869","31867","31868"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：難治てんかんに対する迷走神経刺激療法（ＶＮＳ）のレスポンダーを規定する因子（バイオマーカー）を明かにするため、VNS前後の脳波の特徴と治療成績を比較検討し、さらに、低周波経皮刺激装置を用いた脳の賦活を応用し、より効率の良いＶＮＳ手術適応条件を見いだすことを目的とした。VNS症例45例のうち、フォローアップが可能であった35例を後方視的に解析したところ、24例で発作頻度が半分以下に減少し、3例で抗てんかん薬の減量に至った。また、VNSレスポンダーと非レスポンダーにおける脳波を比較したところ、VNSによる陽性の緩変動電位が発作抑制効果と相関することを明らかにした。\n研究成果の概要（英文）：Vagus nerve stimulation therapy (VNS) is a palliative treatment option for patients with intractable epilepsy who are not good candidates for surgical resection. The biomarker for responder to VNS is, however, not well known. We investigated the clinical features of VNS responders after starting stimulation. We also analyzed routine clinical electroencephalograms (EEGs) from 24 patients who were undergoing seizure treatment by VNS. We compared SCPs at 5 electrodes (around Cz) between the 2 states of VNS: stimulation period and inter-stimulation period. As the results, a positive shift of SCP correlated significantly with seizure reduction, and could be a surrogate marker for VNS response.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26462223;   研究分野：脳神経外科;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26462223/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KATO, Amami"},{"subitem_text_language":"en","subitem_text_value":"IKEDA, Akio"},{"subitem_text_language":"en","subitem_text_value":"NAKANO, Naoki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"京都大学大学院医学研究科; 特定教授"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"},{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"加藤, 天美"},{"creatorName":"カトウ, アマミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"池田, 昭夫"},{"creatorName":"イケダ, アキオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中野, 直樹"},{"creatorName":"ナカノ, ナオキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26462223seika.pdf","filesize":[{"value":"97.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26462223seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18843/files/26462223seika.pdf"},"version_id":"067c2f30-db69-4cc5-b4a7-52f5add86fcb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"難治てんかん","subitem_subject_scheme":"Other"},{"subitem_subject":"迷走神経刺激療法","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカ","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"迷走神経刺激療法におけるレスポンダーのバイオマーカーの探求","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"迷走神経刺激療法におけるレスポンダーのバイオマーカーの探求"},{"subitem_title":"Investigation of biomarkers for responders in vagus nerve stimulation therapy","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18843","relation_version_is_last":true,"title":["迷走神経刺激療法におけるレスポンダーのバイオマーカーの探求"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:47:21.437107+00:00"}