{"created":"2023-06-20T16:47:12.383304+00:00","id":18842,"links":{},"metadata":{"_buckets":{"deposit":"051aaa8f-ed6d-4d2b-b35b-c913900ddb0c"},"_deposit":{"created_by":3,"id":"18842","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18842"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018842","sets":["14:2667:4374"]},"author_link":["31866"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：今回、ミゾリビン（MZR）吸収における個体差がhCNT1、hCNT2、hCNT 3の遺伝子多型に関連するかについて検討した。hCNT1,2,3の遺伝子多型とMZR血中濃度の間には明らかな有意な関係は認めなかった。hCNT1,2,3の遺伝子多型の各組合せとMZR血中濃度の間にも明らかな有意な関係は認められなかった。MZR血中濃度上昇例と非上昇例に分けた検討にても、性別、hCNT1,2,3の遺伝子多型との間には優位な関係はなかった。以上結果より、hCNT1、hCNT2、hCNT 3のそれぞれの遺伝子多型、および組み合わせにおいても、MZR血中濃度の間には明らかな関係性が認められないことを見出した。\n研究成果の概要（英文）：In this study, we investigated whether individual differences in mizoribine (MZR) absorption are related to gene polymorphisms of hCNT1, hCNT2, hCNT 3. There was no clear significant relationship between gene polymorphisms of hCNT 1, 2, 3 and MZR blood concentrations. There was no clear significant relationship between each combination of gene polymorphisms of hCNT 1, 2, 3 and MZR blood concentration. Even in the study divided into MZR blood level elevation cases and non-elevation cases, there was no dominant relationship between gender and hCNT 1, 2, 3 gene polymorphism. From the above results, it was found that no clear relationship was found between MZR blood concentrations in hCNT1, hCNT2, and hCNT 3 gene polymorphisms and combinations, respectively.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26461626;   研究分野：小児科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461626/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"OKADA, MITSURU"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"岡田, 満"},{"creatorName":"オカダ, ミツル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26461626seika.pdf","filesize":[{"value":"262.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26461626seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18842/files/26461626seika.pdf"},"version_id":"8415d9ae-8185-4040-97cc-554f7b30ef87"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"医学","subitem_subject_scheme":"Other"},{"subitem_subject":"薬物動態","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝子多型","subitem_subject_scheme":"Other"},{"subitem_subject":"トランスポーター","subitem_subject_scheme":"Other"},{"subitem_subject":"ミゾリビン","subitem_subject_scheme":"Other"},{"subitem_subject":"Na依存性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ミゾリビン吸収における濃縮型拡散トランスポーターの関与","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ミゾリビン吸収における濃縮型拡散トランスポーターの関与"},{"subitem_title":"Involvement of the concentrative nucleoside transporter on mizoribine absorption syo","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18842","relation_version_is_last":true,"title":["ミゾリビン吸収における濃縮型拡散トランスポーターの関与"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:47:25.457185+00:00"}