{"created":"2023-06-20T16:47:09.906281+00:00","id":18794,"links":{},"metadata":{"_buckets":{"deposit":"cc6158ac-7a2f-4ac0-b792-3a92f75ba1ad"},"_deposit":{"created_by":3,"id":"18794","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18794"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018794","sets":["14:2667:4374"]},"author_link":["31757","31756"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：私たちはこれまでに、BNIP3 はオートファジーを介して表皮分化促進効果を持つことを明らかとした。一方、BNIP3 は UVB 照射による アポトーシスから細胞を保護し、皮膚表皮の形態維持に関与していることも明らかとしている。今回私たちは、UVB照射によるBNIP3の発現は、活性酸素ならびにERK, JNK MAPキナーゼによって制御されていること、BNIP3がオートファジー（マイトファジー）を起こすことで、UVB照射により傷ついたミトコンドリアを分解することでアポトーシスを抑制することを見出した。以上の結果は皮膚炎の治療薬やアンチエイジングに応用出来ることが期待される。\n研究成果の概要（英文）：Previously, we found that BNIP3 plays a crucial role in keratinocytes differentiation by inducing autophagy. Furthermore, BNIP3 has a protective effect against UVB-induced apoptosis in keratinocytes. In this study, we found that the accumulation of reactive oxygen species (ROS) and following activation of ERK/JNK MAP kinase by UVB irradiation was sufficient to trigger the upregulation of BNIP3 expression. Moreover, BNIP3 was required for the degradation of dysfunctional mitochondria upon UVB irradiation. These data clearly indicated that BNIP3-induced autophagy, which occurs via UVB-generated ROS-mediated JNK and ERK MAPK activation, has a crucial role in the protection of the skin epidermis against UVB irradiation.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26461672;   研究分野：皮膚科学,幹細胞生物学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26461672/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MORIYAMA, Mariko"},{"subitem_text_language":"en","subitem_text_value":"MORIYAMA Hiroyuki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学総合研究所; 准教授"},{"subitem_text_value":"近畿大学・薬学総合研究所・准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"森山, 麻里子"},{"creatorName":"モリヤマ, マリコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"森山, 博由"},{"creatorName":"モリヤマ, ヒロユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26461672seika.pdf","filesize":[{"value":"208.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26461672seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18794/files/26461672seika.pdf"},"version_id":"fa243b94-2e51-42e3-86e6-1b8d0a96ca09"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オートファジー","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"},{"subitem_subject":"紫外線","subitem_subject_scheme":"Other"},{"subitem_subject":"ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"皮膚","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"オートファジーは皮膚を紫外線・ストレスによるアポトーシスから防御しているのか？","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"オートファジーは皮膚を紫外線・ストレスによるアポトーシスから防御しているのか？"},{"subitem_title":"Is autophagy involved in the protection of skin epidermis from UV induced apoptosis?","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18794","relation_version_is_last":true,"title":["オートファジーは皮膚を紫外線・ストレスによるアポトーシスから防御しているのか？"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:49:40.560602+00:00"}