{"created":"2023-06-20T16:47:09.641341+00:00","id":18790,"links":{},"metadata":{"_buckets":{"deposit":"09b6e733-1d3e-4398-8f76-5f30fb67de2b"},"_deposit":{"created_by":3,"id":"18790","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18790"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018790","sets":["14:2667:4374"]},"author_link":["31750","31751","31749"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2017","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2016)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：核内蛋白HMGB1はdamage-associated molecular patternsとして、病態時に細胞外に放出される。今回は、癌化学療法誘起神経障害性疼痛および内臓痛におけるHMGB1の役割を解析した。その結果、HMGB1は、RAGE、Toll-like receptor 4、CXCR4などの細胞膜受容体を介して癌化学療法誘起神経障害性疼痛や膵炎に伴う膵臓痛の発症および維持に関与することが明らかとなった。\n研究成果の概要（英文）：HMGB1, a nuclear protein, is released into the extracellular space and plays a role as one of damage-associated molecular patterns in pathological conditions. Here we analyzed the role of HMGB1 in chemotherapy-induced neuropathic pain and visceral pain. Our data indicate that HMGB1 participates in the development and maintenance of chemotherapy-induced neuropathic pain and pancreatitis-related pain.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2014～2016;   課題番号：26460710;   研究分野：薬理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26460710/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者/研究分担者/研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAWABATA, Atsufumi"},{"subitem_text_language":"en","subitem_text_value":"SEKIGUCHI, Fumiko"},{"subitem_text_language":"en","subitem_text_value":"TSUBOTA, Maho"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"川畑, 篤史"},{"creatorName":"カワバタ, アツフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"関口, 富美子"},{"creatorName":"セキグチ, フミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"坪田, 真帆"},{"creatorName":"ツボタ, マホ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-11-01"}],"displaytype":"detail","filename":"26460710seika.pdf","filesize":[{"value":"334.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26460710seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18790/files/26460710seika.pdf"},"version_id":"e7992510-8a93-4111-88e4-10c800401d15"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"HMGB1","subitem_subject_scheme":"Other"},{"subitem_subject":"RAGE","subitem_subject_scheme":"Other"},{"subitem_subject":"CXCR4","subitem_subject_scheme":"Other"},{"subitem_subject":"Toll-like receptor 4","subitem_subject_scheme":"Other"},{"subitem_subject":"トロンボモジュリン","subitem_subject_scheme":"Other"},{"subitem_subject":"神経障害性疼痛","subitem_subject_scheme":"Other"},{"subitem_subject":"内臓痛","subitem_subject_scheme":"Other"},{"subitem_subject":"膵臓痛","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"核内蛋白ＨＭＧＢ１を標的とする癌化学療法誘起神経障害性疼痛と内臓痛の予防と治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"核内蛋白ＨＭＧＢ１を標的とする癌化学療法誘起神経障害性疼痛と内臓痛の予防と治療"},{"subitem_title":"Prevention and treatment of chemotherapy-induced neuropathic pain and visceral pain by targeting HMBG1, a nuclear protein","subitem_title_language":"en"}]},"item_type_id":"8","owner":"3","path":["4374"],"pubdate":{"attribute_name":"公開日","attribute_value":"2017-11-01"},"publish_date":"2017-11-01","publish_status":"0","recid":"18790","relation_version_is_last":true,"title":["核内蛋白ＨＭＧＢ１を標的とする癌化学療法誘起神経障害性疼痛と内臓痛の予防と治療"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T21:49:48.091774+00:00"}