{"created":"2023-06-20T16:46:42.347140+00:00","id":18242,"links":{},"metadata":{"_buckets":{"deposit":"9bb1c62c-2b3f-4dd4-95c3-b7fbeec6016f"},"_deposit":{"created_by":3,"id":"18242","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"18242"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018242","sets":["14:923:1809:4306"]},"author_link":["30813","30814","30815","30816","30817","30818","30819","30820"],"control_number":"18242","item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016-12-15","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"25","bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"かやのもり：近畿大学産業理工学部研究報告","bibliographic_titleLang":"ja"},{"bibliographic_title":"Reports of Faculty of Humanity-Oriented Science and Engineering, Kindai University","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"RNA interference (RNAi) is a genetic regulation system induced by small RNAs. There are two pathways in RNAi, one is induced by small interfering RNA (siRNA) and the other by micro RNA (miRNA). siRNA is a full matched 21-23nt dsRNA and thought to evolutionally develop as a biological defense mechanism against RNA viruses. On the other hand, miRNA is an endogenously transcribed 20-25nt dsRNA having two or three mismatches and is involved in various biological processes. Based on structural and mechanistic similarities and differences between siRNA and miRNA, RNAi efficiencies of siRNAs with 3 mismatches at 2, 10 and 14 positions and siRNAs with 2 mismatches at 2 and 14 positions were evaluated. As a result, siRNA bearing a mismatch at central position showed weaker RNAi effect than siRNAs with no mismatch at central position. It can be concluded that RNAi by Ago2-RISC is stronger than that by Ago1-RISC.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15100/0000018242","subitem_identifier_reg_type":"JaLC"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学産業理工学部"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"13495801","subitem_source_identifier_type":"ISSN"}]},"item_2_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学大学院産業理工学研究科産業理工学専攻"},{"subitem_text_value":"近畿大学大学院産業理工学研究科産業理工学専攻"},{"subitem_text_value":"近畿大学大学院産業理工学研究科産業理工学専攻"},{"subitem_text_value":"近畿大学大学院産業理工学研究科産業理工学専攻"},{"subitem_text_value":"近畿大学産業理工学部生物環境化学科"},{"subitem_text_value":"近畿大学大学院産業理工学研究科産業理工学専攻"},{"subitem_text_value":"近畿大学産業理工学部生物環境化学科; 准教授"},{"subitem_text_value":"近畿大学産業理工学部生物環境化学科; 教授"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"新貝, 恭広","creatorNameLang":"ja"},{"creatorName":"シンカイ, ヤスヒロ","creatorNameLang":"ja-Kana"},{"creatorName":"Shinkai,Yasuhiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"柏原, 慎一","creatorNameLang":"ja"},{"creatorName":"カシハラ, シンイチ","creatorNameLang":"ja-Kana"},{"creatorName":"Kashihara,Shinichi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"藤井, 啓史","creatorNameLang":"ja"},{"creatorName":"フジイ, ヒロフミ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujii,Hirohumi","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"峰松, 剛","creatorNameLang":"ja"},{"creatorName":"ミネマツ, ゴウ","creatorNameLang":"ja-Kana"},{"creatorName":"Minematsu,Go","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"吉永, 尚平","creatorNameLang":"ja"},{"creatorName":"ヨシナガ, ショウヘイ","creatorNameLang":"ja-Kana"},{"creatorName":"Yoshinaga,Shouhei","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"苗村, 円佳","creatorNameLang":"ja"},{"creatorName":"ナエムラ, マドカ","creatorNameLang":"ja-Kana"},{"creatorName":"Naemura,Madoka","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"神武, 洋二郎","creatorNameLang":"ja"},{"creatorName":"コウタケ, ヨウジロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Kotake,Yojiro","creatorNameLang":"en"}],"nameIdentifiers":[{}]},{"creatorAffiliations":[{"affiliationNames":[{"affiliationName":"近畿大学","affiliationNameLang":"ja"},{"affiliationName":"Kindai University","affiliationNameLang":"en"}]}],"creatorNames":[{"creatorName":"藤井, 政幸","creatorNameLang":"ja"},{"creatorName":"フジイ, マサユキ","creatorNameLang":"ja-Kana"},{"creatorName":"Fujii,Masayuki","creatorNameLang":"en"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2017-01-13"}],"displaytype":"detail","filename":"AA12013209-20161215-0001.pdf","filesize":[{"value":"1.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA12013209-20161215-0001.pdf","url":"https://kindai.repo.nii.ac.jp/record/18242/files/AA12013209-20161215-0001.pdf"},"version_id":"a09ec892-8928-45e6-ae70-24000273f86d"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"RNA interference","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"siRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"miRNA","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"mismatch","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"DICER","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hAgo1","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hAgo2","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"RISC","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"〈論文・報告〉miRNA様siRNAによる遺伝子サイレンシング効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"〈論文・報告〉miRNA様siRNAによる遺伝子サイレンシング効果","subitem_title_language":"ja"},{"subitem_title":"Gene Silencing by miRNA-like siRNA","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["4306"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2017-01-13"},"publish_date":"2017-01-13","publish_status":"0","recid":"18242","relation_version_is_last":true,"title":["〈論文・報告〉miRNA様siRNAによる遺伝子サイレンシング効果"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-15T00:18:56.379714+00:00"}