{"created":"2023-06-20T16:46:37.225165+00:00","id":18132,"links":{},"metadata":{"_buckets":{"deposit":"f72884f8-ee73-4b8a-8a1a-261cf3e87367"},"_deposit":{"created_by":29,"id":"18132","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18132"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018132","sets":["14:2667:4296"]},"author_link":["30535"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：松果体はメラトニン以外の液性因子も合成分泌するにもかかわらず、それらの生理機能はほとんど明らかになっていない。メラトニン産生CBA/Nマウスとメラトニン欠損C57BL/6マウスを用いて、松果体除去が概日リズムに及ぼす影響を解析したところ、松果体除去は時差ぼけの回復を加速し、光刺激に対する時計中枢であるSCNの感受性を増加させることが分かった。この変化を生じた物質を探索すると、松果体によって分泌されるメラトニン前駆体セロトニンが脳髄液を介してSCNに作用し、光に対する感受性を抑制していることを発見した。メラトニン以外の松果体液性因子における生理機能の解明は初めてである。\n研究成果の概要（英文）：The functions of humoral factors except melatonin in the pineal body on the light entrainment of the circadian rhythm have not been fully investigated. In melatonin-proficient CBA/N or melatonin-deficient C57BL/6 mice, pinealectomy induced faster resetting for jet-lag. Administration of melatonin to the pinealectomized CBA/N mice did not modify the recovery from the jet lag. 5-HT showed apparent effects on the light resetting process. 5-HT delayed the resetting of locomotor activity rhythm after an abrupt shift of LD cycle, and attenuated the pinealectomy-enhanced phase shift of the circadian locomotor activity as well as c-Fos induction in the SCN after a light pulse during the night. In contrast, 5-HT synthesis inhibitor generated increase of the phase shift as well as increase in c-Fos induction by light. The findings suggest that pineal 5-HT suppresses light entrainment by attenuating the light signal transduction to the central circadian clock in the SCN.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2014～2015;   課題番号：26860163;   研究分野：動物生理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26860163/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"IKEGAMI, Keisuke"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"池上, 啓介"},{"creatorName":"イケガミ, ケイスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-14"}],"displaytype":"detail","filename":"26860163seika.pdf","filesize":[{"value":"216.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"26860163seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18132/files/26860163seika.pdf"},"version_id":"550cff15-94e1-41ae-8b11-a3fdacc01b4c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"松果体","subitem_subject_scheme":"Other"},{"subitem_subject":"視交叉上核","subitem_subject_scheme":"Other"},{"subitem_subject":"概日時計","subitem_subject_scheme":"Other"},{"subitem_subject":"メラトニン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"哺乳類の概日活動リズム制御機構における新規松果体液性因子の探索","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"哺乳類の概日活動リズム制御機構における新規松果体液性因子の探索"},{"subitem_title":"Search of the novel pineal humoral factor in a mammalian circadian system","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-14"},"publish_date":"2016-10-14","publish_status":"0","recid":"18132","relation_version_is_last":true,"title":["哺乳類の概日活動リズム制御機構における新規松果体液性因子の探索"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:07:30.259559+00:00"}