{"created":"2023-06-20T16:46:36.771501+00:00","id":18125,"links":{},"metadata":{"_buckets":{"deposit":"8f14e060-fed0-461c-89ae-0a79ca0a062e"},"_deposit":{"created_by":29,"id":"18125","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18125"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018125","sets":["14:2667:4296"]},"author_link":["30524","30523","30522"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：これまでの耳介形状軟骨の再生誘導の研究では、良好な軟骨再生と耳介特有の複雑な３次元形状を長期維持する2点が大きな課題として残されている。本研究では、良好な軟骨再生を誘導する目的でナノテクノロジー技術を導入し、ポリグリコール酸（PGA）不織布の繊維径が播種細胞効率および軟骨再生に及ぼす影響について検討を行った。その結果、平均繊維径が0.8～3μmの細径PGA不織布を用いることにより、軟骨再生は促進され、長期の３次元形状維持も良好となることが判明した。ナノテクノロジー技術を導入して作製した細径PGA 不織布は、耳介形成手術における新しいオプションとして、将来重要な役割を果たすことが示唆された。\n研究成果の概要（英文）：In conventional studies on the regeneration of auricle-shaped cartilage in autogenous models using large animals, there were problems with the cartilage regeneration induction capacity and long-term retention of geometric shape. In this study, we sought to improve upon outcome in these regards: a non-woven fabric of polyglycolic acid (PGA) was developed through nanotechnology, evaluating the effect of nanofiber diameter on in vitro cell-seeding efficiency, and in vivo response after implantation in an autogenous large-animal model. Optimal cell maintenance and neocartilage response were seen with PGA fiber diameters of 0.8-3.0 μm for nano-fiber constructs. Biomechanical strength was optimal for PGA fiber diametersin in the same mid-range. These findings demonstrate the potential for nano-scale modulation of auricle-shaped cartilage regeneration in a large-animal model.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2013～2015;   課題番号：25462806;   研究分野：医歯薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25462806/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ISOGAI, Noritaka"},{"subitem_text_language":"en","subitem_text_value":"KUSUHARA, Hirohisa"},{"subitem_text_language":"en","subitem_text_value":"MOROTOMI, Tadaaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"磯貝, 典孝"},{"creatorName":"イソガイ, ノリタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"楠原, 廣久"},{"creatorName":"クスハラ, ヒロヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"諸富, 公昭"},{"creatorName":"モロトミ, タダアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-14"}],"displaytype":"detail","filename":"25462806seika.pdf","filesize":[{"value":"173.8 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25462806seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18125/files/25462806seika.pdf"},"version_id":"53f59761-8236-4452-8e99-efdf9d3fa669"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"PGA","subitem_subject_scheme":"Other"},{"subitem_subject":"ナノファイバー","subitem_subject_scheme":"Other"},{"subitem_subject":"耳介軟骨","subitem_subject_scheme":"Other"},{"subitem_subject":"再生誘導","subitem_subject_scheme":"Other"},{"subitem_subject":"自家移植","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"吸収性ナノファイバーを応用した自家移植モデルにおける耳介形状軟骨の再生誘導","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"吸収性ナノファイバーを応用した自家移植モデルにおける耳介形状軟骨の再生誘導"},{"subitem_title":"Effect of nanofiber PGA in composite scaffolds with polypropylene for fabricating tissue engineered auricle","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-14"},"publish_date":"2016-10-14","publish_status":"0","recid":"18125","relation_version_is_last":true,"title":["吸収性ナノファイバーを応用した自家移植モデルにおける耳介形状軟骨の再生誘導"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:08:31.263762+00:00"}