{"created":"2023-06-20T16:46:36.319195+00:00","id":18118,"links":{},"metadata":{"_buckets":{"deposit":"f28d8668-cc80-45a0-b106-b3c5aa6548fb"},"_deposit":{"created_by":29,"id":"18118","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18118"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018118","sets":["14:2667:4296"]},"author_link":["3264","30503","4038","4011","30504"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：１型糖尿病は膵β細胞が免疫機序により破壊される臓器特異的自己免疫疾患であり、免疫調節機能を明らかにすることが治療につながる。１型糖尿病における免疫調節機能を解明するため、新規１型糖尿病感受性遺伝子の同定を行うとともに、複数の異なる臓器における自己免疫疾患の関連について解析を行い、遺伝子間の関連を明らかにした。新規１型糖尿病感受性遺伝子Mafa遺伝子では、１型のノックアウトマウスを作成し解析をしたところ、Mafa遺伝子が糖尿病発症と膵島炎に関わる遺伝子であることが明らかとなった。\n研究成果の概要（英文）：Type 1 diabetes mellitus is the organ-specific autoimmune disease that β cell in pancreatic islets is destroyed by immune mechanism and to clarify the mechanism of immunoregulation leads to treatment of type 1 diabetes mellitus. To clarify the immunoregulation in the type 1 diabetes mellitus, we identify new genes susceptibility to type 1 diabetes mellitus and analyze correlation between autoimmune diseases in different organs. As a result, we clarified intergenic correlation between autoimmune genes.Then, we established the Mafa(which is the new genes susceptibility to type 1 diabetes mellitus) knockout NOD mouse, it was revealed that the Mafa gene affected the diabetes onset and insulitis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2013～2015;   課題番号：25461368;   研究分野：糖尿病;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461368/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"HIROMINE, Yoshihisa"},{"subitem_text_language":"en","subitem_text_value":"IKEGAMI, Hiroshi"},{"subitem_text_language":"en","subitem_text_value":"KAWABATA, Yumiko"},{"subitem_text_language":"en","subitem_text_value":"NOSO, Shinsuke"},{"subitem_text_language":"en","subitem_text_value":"BABAYA, Naru"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"廣峰, 義久"},{"creatorName":"ヒロミネ, ヨシヒサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"池上, 博司"},{"creatorName":"イケガミ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"川畑, 由美子"},{"creatorName":"カワバタ, ユミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"能宗, 伸輔"},{"creatorName":"ノソ, シンスケ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"馬場谷, 成"},{"creatorName":"ババヤ, ナル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-14"}],"displaytype":"detail","filename":"25461368seika.pdf","filesize":[{"value":"410.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25461368seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18118/files/25461368seika.pdf"},"version_id":"1f58a603-dea8-4a92-9450-66db97ce101f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"１型糖尿病","subitem_subject_scheme":"Other"},{"subitem_subject":"膵島自己免疫","subitem_subject_scheme":"Other"},{"subitem_subject":"臓器特異性","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"１型糖尿病遺伝子解析による免疫制御機構の解明と発症予防への展開","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"１型糖尿病遺伝子解析による免疫制御機構の解明と発症予防への展開"},{"subitem_title":"Elucidation of the control structure of immunity and the onset prevention by the type 1 diabetes mellitus gene analysis","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-14"},"publish_date":"2016-10-14","publish_status":"0","recid":"18118","relation_version_is_last":true,"title":["１型糖尿病遺伝子解析による免疫制御機構の解明と発症予防への展開"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:08:19.474779+00:00"}