{"created":"2023-06-20T16:46:36.190105+00:00","id":18116,"links":{},"metadata":{"_buckets":{"deposit":"2f78a5ab-2e72-4b1b-bc34-7b206e9ddb8d"},"_deposit":{"created_by":29,"id":"18116","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18116"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018116","sets":["14:2667:4296"]},"author_link":["4258"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：喘息の病態を気道平滑筋の表現型の変化として捉え、鍵となる蛋白を検索し、根元的な分子標的治療の確立を目的とした。その結果、病態の大部分は収縮性、増殖性の表現型の変化で生じ、それらの機序として、Ca2+-activated K+ channel/voltage-dependent Ca2+ channel の連関に由来する Ca2+ dynamics、および、RhoA/Rho-kinase 系を介する Ca2+ sensitization の関与を解明した。これらの Ca2+ signaling は、喘息治療のあらたな標的蛋白と考えられる。\n研究成果の概要（英文）：Alteration of contractility in airway smooth muscle (ASM) contributes to airflow limitation, airway hyperresponsiveness (AHR), and beta2-adrenergic desensitization. Alteration of synthesis contributes to airway remodeling via facilitation of the proliferation and migration in ASM. In our observation, Ca2+ dynamics through the large-conductance Ca2+-activated K+ channel/L-type voltage-dependent Ca2+ channel linkage, and Ca2+ sensitization through the RhoA/Rho-kinase pathway contribute not only to alterations in the contractile phenotype involved in airflow limitation, AHR and tolerance to beta2-adrenergic receptors, but also to alteration of the synthetic phenotype involved in airway remodeling. The Ca2+ signaling also contribute to the synergism (cross talk) in combination of beta2-adrenergic receptor agonists with muscarinic receptor antagonists. Therefore, the phenotype change in ASM via the Ca2+ signaling may be a novel target for development of asthmatic agents.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2013～2015;   課題番号：25461201;   研究分野：医歯薬学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461201/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KUME, Hiroaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"久米, 裕昭"},{"creatorName":"クメ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-14"}],"displaytype":"detail","filename":"25461201seika.pdf","filesize":[{"value":"190.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25461201seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18116/files/25461201seika.pdf"},"version_id":"e0115a26-6b1e-42fa-9e71-acfdf881a4c9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"喘息","subitem_subject_scheme":"Other"},{"subitem_subject":"phenotype change","subitem_subject_scheme":"Other"},{"subitem_subject":"気道平滑筋","subitem_subject_scheme":"Other"},{"subitem_subject":"G protein","subitem_subject_scheme":"Other"},{"subitem_subject":"Ca2+ signaling","subitem_subject_scheme":"Other"},{"subitem_subject":"KCa channel","subitem_subject_scheme":"Other"},{"subitem_subject":"Rho-kinase","subitem_subject_scheme":"Other"},{"subitem_subject":"allosteric effect","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"気道平滑筋の遊走能と収縮能の制御に基づく喘息分子標的療法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"気道平滑筋の遊走能と収縮能の制御に基づく喘息分子標的療法"},{"subitem_title":"Molecularly-targeted therapy for asthma with a focus on migration and contractility of airway smooth muscle cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-14"},"publish_date":"2016-10-14","publish_status":"0","recid":"18116","relation_version_is_last":true,"title":["気道平滑筋の遊走能と収縮能の制御に基づく喘息分子標的療法"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:08:14.756527+00:00"}