{"created":"2023-06-20T16:46:35.928428+00:00","id":18112,"links":{},"metadata":{"_buckets":{"deposit":"1c60de89-1874-4316-bac0-323a1650c99c"},"_deposit":{"created_by":29,"id":"18112","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18112"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018112","sets":["14:2667:4296"]},"author_link":["3715","3167"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では骨修復・再生過程でのマクロファージの動態および活性化における組織線溶系の役割を検討した。今回、骨修復・再生過程において組織線溶系が中心的な役割を果たすことが明らかになった。さらに、組織線溶系は骨修復・再生部位にマクロファージを集積させ、それらの活性化に寄与することで骨修復に寄与することが明らかになった。今後、組織線溶系を標的としたマクロファージの機能調節により、効率よく骨修復・再生を亢進する方法の確立を目指してさらに研究を進めたい。\n研究成果の概要（英文）：We aimed to investigate the role of the tissue fibrinolytic system in macrophage accumulation and their activation during bone repair and regeneration. We found that the tissue fibrinolytic system plays a crucial role in bone repair and regeneration. Moreover, the tissue fibrinolytic system contributes to macrophage accumulation at the damaged site of bone defect and their activation during bone repair. Since these findings suggest that the tissue fibrinolytic system is critical for the formation of a suitable microenvironment for bone repair and regeneration through macrophage accumulation and activation, the spatiotemporal regulation of the tissue fibrinolytic system is a promising strategy to meet the clinical needs for the regeneration of bone tissue for reconstruction. We would like to proceed the further study of the regulation of macrophage functions by the tissue fibrinolytic system for the development of the effective bone repair and regeneration.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2013～2015;   課題番号：25460305;   研究分野：生理学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460305/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KAWAO, Naoyuki"},{"subitem_text_language":"en","subitem_text_value":"KAJI, Hiroshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"河尾, 直之"},{"creatorName":"カワオ, ナオユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"梶, 博史"},{"creatorName":"カジ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-14"}],"displaytype":"detail","filename":"25460305seika.pdf","filesize":[{"value":"176.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25460305seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18112/files/25460305seika.pdf"},"version_id":"04837801-403b-4668-b031-606f4a6ae15a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"組織線溶系","subitem_subject_scheme":"Other"},{"subitem_subject":"マクロファージ","subitem_subject_scheme":"Other"},{"subitem_subject":"骨修復・再生","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"組織線溶系によるマクロファージを介した新規な骨・軟骨再生機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"組織線溶系によるマクロファージを介した新規な骨・軟骨再生機構"},{"subitem_title":"Novel mechanisms of bone regeneration induced by the tissue fibrinolytic system through macrophage regulation","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-14"},"publish_date":"2016-10-14","publish_status":"0","recid":"18112","relation_version_is_last":true,"title":["組織線溶系によるマクロファージを介した新規な骨・軟骨再生機構"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:08:05.978779+00:00"}