{"created":"2023-06-20T16:46:35.733300+00:00","id":18109,"links":{},"metadata":{"_buckets":{"deposit":"c90b9f39-5236-412a-9abb-147acb06f83f"},"_deposit":{"created_by":29,"id":"18109","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18109"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018109","sets":["14:2667:4296"]},"author_link":["30482","30483"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：赤ブドウの果皮などの食品に含まれるレスベラトロール誘導体(RVD)の腫瘍細胞に対する増殖抑制作用の機序を、分子生物学的手法を用いて解析した。その結果、①一般に活性酸素濃度が亢進しているとされるがん細胞ではMIFという炎症性サイトカインの１つであるタンパク質が、転写因子であるNFｋB に直接働きかけ、その下流にあるJNKというアポトーシス誘導シグナル因子を抑制する、②MIFはRVDと結合することにより、NFｋBを経て、JNKの抑制ができなくなり、細胞にアポトーシスをもたらすことがわかった。したがって、RVDは、MIFを標的としたがん治療薬のリード化合物となる可能性が示唆された。\n研究成果の概要（英文）：Derivatives of resveratrol (RVD) that is included in several foods such as grape skin exert anti-proliferative effect on cancer-derived cells. The mode of action regarding to this effect was investigated using molecular biological methods. We found that one inflammatory cytokine called “MIF” interacts with a transcription factor “NFKB”, which down-regulates “JNK”, an apoptosis-inducible signal molecule, thereby avoiding apoptosis induced by reactive oxygen species (ROS). RVDs can prevent MIF from performing this cell protecting effect by direct binding to MIF, resulting in apoptosis. Therefore, RVDs could be promising lead compounds for the development of a therapeutic agents to fight against cancer.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2013～2015;   課題番号：25350979;   研究分野：総合生物;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25350979/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"FUJITA, Yoshihiko"},{"subitem_text_language":"en","subitem_text_value":"OKAWARA, Tadashi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"熊本科学保健大学保健科学部; 教授"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤田, 至彦"},{"creatorName":"フジタ, ヨシヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30482","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"80192730","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"大川原, 正"},{"creatorName":"オオカワラ, タダシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"30483","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60040325","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-14"}],"displaytype":"detail","filename":"25350979seika.pdf","filesize":[{"value":"276.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25350979seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18109/files/25350979seika.pdf"},"version_id":"9f0cbf6f-dabf-4e07-88c2-87c061cdb9dc"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"レスベラトロール","subitem_subject_scheme":"Other"},{"subitem_subject":"MIF","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"レスベラトロールのアザ誘導体化合物による細胞増殖抑制機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レスベラトロールのアザ誘導体化合物による細胞増殖抑制機構の解明"},{"subitem_title":"Mechanism of anti-proliferative effect of resveratrol derivatives on cancer cells","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-14"},"publish_date":"2016-10-14","publish_status":"0","recid":"18109","relation_version_is_last":true,"title":["レスベラトロールのアザ誘導体化合物による細胞増殖抑制機構の解明"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:08:00.337605+00:00"}