{"created":"2023-06-20T16:46:35.428838+00:00","id":18103,"links":{},"metadata":{"_buckets":{"deposit":"b7942398-fdc8-4d13-a99e-47f122409fbd"},"_deposit":{"created_by":29,"id":"18103","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18103"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018103","sets":["14:2667:4296"]},"author_link":["30467","30461","30462","30463","3717","30464","30466","30465"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：本研究では、食道扁平上皮癌に対する化学療法、放射線化学療法の治療早期におけるp53-Ser46のリン酸化をバイオマーカーとした治療効果予測の有用性を検討し、実際に生検組織の検討でp53-Ser46のリン酸化の誘導を治療開始翌日の生検で初めて臨床的に確認したが、治療開始後早期のSer46リン酸化の有無と化学療法や化学放射線療法の治療効果との間には明らかな相関は認めなかった。CRが得られた症例の中にはp53 mutant/Ser-46リン酸化陰性例も認められており、今回の検討から化学療法や化学放射線療法に対する効果はp53によるアポトーシス経路のみでなく、他の要因も関わることが示唆された。\n研究成果の概要（英文）：In this study, we examined the usefulness of induction of the phosphorylation of p53-Ser46 the next day after initiation of treatment as a biomarker of the prediction of treatment response of chemotherapy/chemoradiotherapy for esophageal squamous cell carcinoma. We confirmed the fact for the first time that the phosphorylation of p53-Ser-46 was induced by chemotherapy/chemoradiotherapy in the early stage of treatment. However, there was no significant correlation between the phosphorylation of p-53-Ser-46 and treatment response. Among cases obtained complete response to preoperative therapy, the cases with p-53 mutant and no induction of Ser-46 phosphorylation were involved, therefore, these results suggested that the effect on chemotherapy and chemoradiotherapy was caused not only by apoptosis thorough p53 pathway, but also by another pathway associating with other factors.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2012～2015;   課題番号：24591962;   研究分野：食道癌集学的治療;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591962/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YASUDA, Takushi"},{"subitem_text_language":"en","subitem_text_value":"IMAMOTO, Haruhiko"},{"subitem_text_language":"en","subitem_text_value":"IMANO, Motohiro"},{"subitem_text_language":"en","subitem_text_value":"SHINKAI, Masayuki"},{"subitem_text_language":"en","subitem_text_value":"YASUDA, Atsushi"},{"subitem_text_language":"en","subitem_text_value":"SHIRAISHI, Osamu"},{"subitem_text_language":"en","subitem_text_value":"IWAMA, Mitsuru"},{"subitem_text_language":"en","subitem_text_value":"KATO, Hiroaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"安田, 卓司"},{"creatorName":"ヤスダ, タクシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"今本, 治彦"},{"creatorName":"イマモト, ハルヒコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"今野, 元博"},{"creatorName":"イマノ, モトヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"新海, 政幸"},{"creatorName":"シンカイ, マサユキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"安田, 篤"},{"creatorName":"ヤスダ, アツシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"白石, 治"},{"creatorName":"シライシ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"岩間, 密"},{"creatorName":"イワマ, ミツル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"加藤, 寛章"},{"creatorName":"カトウ, ヒロアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-14"}],"displaytype":"detail","filename":"24591962seika.pdf","filesize":[{"value":"409.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"24591962seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18103/files/24591962seika.pdf"},"version_id":"f68dfc4a-bbe6-4e8c-af0f-64c106fb0170"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"p53-Ser-46","subitem_subject_scheme":"Other"},{"subitem_subject":"食道扁平上皮癌","subitem_subject_scheme":"Other"},{"subitem_subject":"治療効果予測","subitem_subject_scheme":"Other"},{"subitem_subject":"リン酸化誘導","subitem_subject_scheme":"Other"},{"subitem_subject":"バイオマーカー","subitem_subject_scheme":"Other"},{"subitem_subject":"アポトーシス","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ｐ５３遺伝子変異と治療早期のＳｅｒ４６リン酸化誘導からみた食道癌個別化治療戦略","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ｐ５３遺伝子変異と治療早期のＳｅｒ４６リン酸化誘導からみた食道癌個別化治療戦略"},{"subitem_title":"The study of the significance of the phosphorylation of p53 Ser46 in the prediction of response to preoperative chemotherapy or chemoradiotherapy for advanced esophageal cancer.","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-14"},"publish_date":"2016-10-14","publish_status":"0","recid":"18103","relation_version_is_last":true,"title":["ｐ５３遺伝子変異と治療早期のＳｅｒ４６リン酸化誘導からみた食道癌個別化治療戦略"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:09:06.424412+00:00"}