{"created":"2023-06-20T16:46:34.317024+00:00","id":18078,"links":{},"metadata":{"_buckets":{"deposit":"6626474c-532c-4329-87b8-d6d74e8b6098"},"_deposit":{"created_by":29,"id":"18078","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18078"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018078","sets":["14:2667:4296"]},"author_link":["3141"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：オキサリプラチン誘発末梢神経障害の発症メカニズムについて解析を行い、腰髄部分（lumber 4～6）におけるProtein kinase C（PKC）活性化に基づくERK/c-Fos経路の活性化が関与することを見出した。また、PKCを阻害する分子標的薬によりERK/c-Fos経路の抑制を介してオキサリプラチン誘発末梢神経障害を阻害することを明らかにした。以上の結果は、臨床におけるオキサリプラチン誘発末梢神経障害発症時における治療に貢献できる可能性が考えられる。なお、本研究成果は主な発表論文の項に全てまとめてある。\n研究成果の概要（英文）：I show that oxaliplatin induces the neuropathy through the activation of PKC/ERK/c-Fos pathway in lumber spinal cords. In addition, PKC inhibitor suppressed the oxaliplatin-induced neuropathy via PKC pathways. These findings suggest that PKC inhibitors are potentially useful for oxaliplatin-induced neuropathy. As well, These results are summarized as section of presented paper.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2013～2015;   課題番号：25860071;   研究分野：薬物治療学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860071/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TSUBAKI, Masanobu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"椿, 正寛"},{"creatorName":"ツバキ, マサノブ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-17"}],"displaytype":"detail","filename":"25860071seika.pdf","filesize":[{"value":"293.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25860071seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18078/files/25860071seika.pdf"},"version_id":"551ea8a9-2566-4921-8621-d67a251fea7e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"オキサリプラチン","subitem_subject_scheme":"Other"},{"subitem_subject":"末梢神経障害","subitem_subject_scheme":"Other"},{"subitem_subject":"分子標的薬","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"分子標的薬によるオキサリプラチン誘発末梢神経障害の治療法の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"分子標的薬によるオキサリプラチン誘発末梢神経障害の治療法の開発"},{"subitem_title":"Therapeutic strategy for oxaliplatin-induced neuropathy by mulecular targeting drugs","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-17"},"publish_date":"2016-10-17","publish_status":"0","recid":"18078","relation_version_is_last":true,"title":["分子標的薬によるオキサリプラチン誘発末梢神経障害の治療法の開発"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:09:20.838623+00:00"}