{"created":"2023-06-20T16:46:34.051897+00:00","id":18072,"links":{},"metadata":{"_buckets":{"deposit":"a3fd104e-0d22-4420-9573-8ffbc82adbf6"},"_deposit":{"created_by":29,"id":"18072","owners":[29],"pid":{"revision_id":0,"type":"depid","value":"18072"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00018072","sets":["14:2667:4296"]},"author_link":["3299","30677","30678"],"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2016","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2015)"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）：慢性ストレスはがん転移にどのような影響を与えるのか肺がん転移モデルを使用して検討した。その結果以下の知見を得た。（1）肺がん転移モデルにおいて慢性ストレスによりがん転移ならびに腫瘍増大は促進した。（2）慢性ストレスマウスは、肺のNK細胞やマクロファージ数が減少し、マクロファージの貪食能が低下していた。すなわち、慢性ストレスは肺胞マクロファージの免疫能を低下によりがん転移や腫瘍増大を促進させることが示唆された。\n研究成果の概要（英文）：We investigated whether chronic stress influences on cancer metastatic ability using a lung cancer metastasis model B16BL6 cell. As a result, we obtained the following findings. 1) The cancer metastasis and the tumor growth in B16BL6 cell were promoted in chronically stressed mice. 2) The number of NK cell and alveolar macrophage and the phagocytic activity of the macrophage in the chronically stressed mice were decreased. It is suggested from these results suggest that the cancer metastatic ability of B16BL6 cell in chronically stressed mice is prompted so that the immunocompetence of the alveolar macrophage is decreased in the chronically stressed mice.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2013～2015;   課題番号：25460918;   研究分野：ストレス科学;   科研費の分科・細目：","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460918/"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ICHIDA, Seiji"},{"subitem_text_language":"en","subitem_text_value":"NISHIDA, Shozo"},{"subitem_text_language":"en","subitem_text_value":"FUNAKAMI, Yoshinori"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 講師"},{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学薬学部; 講師"}]},"item_8_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kindai University"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"市田, 成志"},{"creatorName":"イチダ, セイジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"西田, 升三"},{"creatorName":"ニシダ, ショウゾウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"船上, 仁範"},{"creatorName":"フナカミ, ヨシノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-10-17"}],"displaytype":"detail","filename":"25460918seika.pdf","filesize":[{"value":"195.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"25460918seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/18072/files/25460918seika.pdf"},"version_id":"883ece49-05bd-46ab-8c7f-76935f155c56"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"慢性ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"がん","subitem_subject_scheme":"Other"},{"subitem_subject":"転移","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"慢性ストレス状態は癌細胞の転移能を増大する","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"慢性ストレス状態は癌細胞の転移能を増大する"},{"subitem_title":"Chronic stress state promotes cancer metastatic ability","subitem_title_language":"en"}]},"item_type_id":"8","owner":"29","path":["4296"],"pubdate":{"attribute_name":"公開日","attribute_value":"2016-10-17"},"publish_date":"2016-10-17","publish_status":"0","recid":"18072","relation_version_is_last":true,"title":["慢性ストレス状態は癌細胞の転移能を増大する"],"weko_creator_id":"29","weko_shared_id":-1},"updated":"2023-06-20T22:10:09.463930+00:00"}