{"created":"2023-06-20T16:43:13.614254+00:00","id":14052,"links":{},"metadata":{"_buckets":{"deposit":"3f44cd2d-19c5-4083-ad0e-68f73c4a90a8"},"_deposit":{"created_by":3,"id":"14052","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14052"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014052","sets":["14:2667:2671:2672"]},"author_link":["3833"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of a divergent synthesis of 4—and 5—membered heterocycles and its application to the synthesis of bioactive natural product"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）: 複素環化合物は医薬品や農薬, または機能性材料として広く利用される化合物です. その中でも含酸素4員環化合物であるオキセタン構造は, 医薬品の構造中に導入することで品質動態の向上などが報告されている有用な骨格です. 我々は, これまでにリンと酸素からなるO, P-アセタールという化合物を鍵中間体として, オキセタン構造の簡便な合成法の開発に成功しました. この方法の特徴は, 化合物中のリン原子を一度の反応で2度利用するエコ重視な点です. また, 本法を応用することで抗がん活性を有する天然物を短工程で合成することにも成功しました.          研究成果の概要（英文): Heterocyclic compounds are utilized in pharmaceuticals, agrochemicals and functional materials. Recently, oxygen-containing 4-membered heterocycles, oxetane, has been reported as a useful skeleton to improve a pharmaceutical quality. We developed a facile oxetane synthesis using O,P-acetal consisted of phosphorous and oxygen as a key intermediate. The feature of this method is eco-conscious double use of phosphorous atom in one reaction. We also succeeded in synthesizing natural product having anticancer activity in short steps using our method.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究（B）;  研究期間：2012～2013;   課題番号：24790012;   研究分野：医歯薬学;   科研費の分科・細目：薬学・化学系薬学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/40363890.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MAEGAWA, Tomohiro"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学・薬学部・准教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"前川,  智弘"},{"creatorName":"マエガワ, トモヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_24790012seika.pdf","filesize":[{"value":"185.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_24790012seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14052/files/KAKEN_24790012seika.pdf"},"version_id":"996a9272-615d-4e4e-984b-4187876abf11"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"O, P-アセタール","subitem_subject_scheme":"Other"},{"subitem_subject":"オキセタン","subitem_subject_scheme":"Other"},{"subitem_subject":"複素環合成","subitem_subject_scheme":"Other"},{"subitem_subject":"天然物合成","subitem_subject_scheme":"Other"},{"subitem_subject":"創薬化学","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"多様なヘテロ4員環及び5員環化合物の合成法の開発と生物活性天然物合成への応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"多様なヘテロ4員環及び5員環化合物の合成法の開発と生物活性天然物合成への応用"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-29"},"publish_date":"2014-09-29","publish_status":"0","recid":"14052","relation_version_is_last":true,"title":["多様なヘテロ4員環及び5員環化合物の合成法の開発と生物活性天然物合成への応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:03:36.008110+00:00"}