{"created":"2023-06-20T16:43:13.439087+00:00","id":14048,"links":{},"metadata":{"_buckets":{"deposit":"20d43709-3015-4c29-a5a5-6f834cc13d8f"},"_deposit":{"created_by":3,"id":"14048","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14048"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014048","sets":["14:2667:2671:2672"]},"author_link":["3999"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Detection of EML4-ALK in serum RNA from lung cancer patients"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 本研究では, 肺がんにおいてＡＬＫ阻害剤が著効するＥＭＬ４－ＡＬＫ融合遺伝子の非侵襲的検出法の確立を目的として, 血清検体におけるＥＭＬ４－ＡＬＫ検出を検討した. がん研有明病院の協力を得て, ＥＭＬ４－ＡＬＫ融合遺伝子陽性の患者血清を採取, 収集し, 血清検体からのＥＭＬ４－ＡＬＫ融合遺伝子の検出を検討した. ＥＭＬ４－ＡＬＫの複数存在するバリアントの同時検出および検出感度の向上をめざし, 血清からの核酸抽出方法や測定条件, 鋳型として用いる核酸の種類の検討を行い, 検出方法の最適化を行った. この結果, ＥＭＬ４－ＡＬＫ融合遺伝子陽性患者１２例中２例の患者血清からＥＭＬ４－ＡＬＫ融合遺伝子の検出に成功した.           研究成果の概要（英文): The presence of the transforming fusion gene EML4-ALK in non&","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2012～2013;   課題番号：24701013;   研究分野：総合領域;   科研費の分科・細目：腫瘍学・腫瘍診断学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20580559.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SAKAI, Kazuko"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"坂井,  和子"},{"creatorName":"サカイ, カズコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3999","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20580559","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_24701013seika.pdf","filesize":[{"value":"273.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_24701013seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14048/files/KAKEN_24701013seika.pdf"},"version_id":"d5e3641a-41e8-4251-9073-f0d1fe89992c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"薬効評価と予測","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"血清検体を用いたＥＭＬ４－ＡＬＫ検出","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"血清検体を用いたＥＭＬ４－ＡＬＫ検出"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"14048","relation_version_is_last":true,"title":["血清検体を用いたＥＭＬ４－ＡＬＫ検出"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:03:43.703084+00:00"}