{"created":"2023-06-20T16:43:13.351297+00:00","id":14046,"links":{},"metadata":{"_buckets":{"deposit":"6af379b9-31f8-4904-9013-de3f9808bde0"},"_deposit":{"created_by":3,"id":"14046","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14046"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014046","sets":["14:2667:2671:2672"]},"author_link":["3841"],"control_number":"14046","item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The functional analysis of novel long non-coding RNA regulating p53"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 本研究では, 最近申請者らが網羅的解析によって同定した長鎖ノンコーディングRNA、POLOP（Positive regulator lncRNA of p53）の機能を解明することを目的とした. 本研究の結果, POLOPはヒト骨肉腫細胞で高発現していることが明らかとなった. また, POLOPは抗ガン剤（エトポシド）添加や活性型H-RAS変異体の過剰発現により, 発現誘導されることが分かった. さらにPOLOPをノックダウンすると、ヒト骨肉腫細胞の増殖が顕著に抑制されることが明らかとなった. これらの結果から, POLOPは, 骨肉腫細胞の増殖を促進する機能があることが示唆された.           研究成果の概要（英文): In this study, we aimed the functional analysis of long non-coding RNA, POLOP (Positive regulator lncRNA of p53). We found that POLOP highly expresses in human osteosarcoma cells. The expression of POLOP was induced by the treatment of etoposide and forced expression of H-RASG12V. The depletion of POLOP in human osteosarcoma cells decreased cell growth. These results suggest that POLOP promotes the cell growth of human osteosarcoma cells.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：若手研究(B);  研究期間：2012～2013;   課題番号：24700975;   研究分野：総合領域;   科研費の分科・細目：腫瘍学・腫瘍生物学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ(WEKO2)","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/90531963.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"KOTAKE, Yojiro"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学工学部; 准教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"神武,  洋二郎"},{"creatorName":"コウタケ, ヨウジロウ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{"nameIdentifierURI":""}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_24700975seika.pdf","filesize":[{"value":"116.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_24700975seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14046/files/KAKEN_24700975seika.pdf"},"version_id":"5181f16a-d197-4ca4-a604-7e7015fcaba0"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ノンコーディングRNA","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞増殖","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"ｐ５３を制御する新規長鎖ノンコーディングＲＮＡの機能解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"ｐ５３を制御する新規長鎖ノンコーディングＲＮＡの機能解析","subitem_title_language":"ja"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-10-02"},"publish_date":"2014-10-02","publish_status":"0","recid":"14046","relation_version_is_last":true,"title":["ｐ５３を制御する新規長鎖ノンコーディングＲＮＡの機能解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-09-15T00:26:48.808870+00:00"}