{"created":"2023-06-20T16:43:11.797991+00:00","id":14010,"links":{},"metadata":{"_buckets":{"deposit":"040b598b-897d-4d6a-9691-604976f7dde4"},"_deposit":{"created_by":3,"id":"14010","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14010"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014010","sets":["14:2667:2671:2672"]},"author_link":["3991"],"item_8_alternative_title_3":{"attribute_name":"その他(別言語等)のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Reguratiion for invasion of OSCC by reptin"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文): 癌細胞が細胞外基質を分解する過程は, 癌細胞の浸潤・転移に最も重要な過程である. クロマチンリモデリング因子, reptinは癌転移抑制遺伝子の発現を抑え, 癌の浸潤・転移を制御するという報告されている. 今回2種類のヒト口腔扁平上皮癌細胞株OSC-19細胞およびOSC-20細胞を用いてreptinをノックダウンしたところ, 両者とも遊走能の亢進と細胞形態の紡錘形変化を認めた. 上皮系マーカーであるE-cadherinの発現が低下と間葉系マーカーであるN-cadherinの発現の上昇を認めた. 以上の結果よりreptinはEMTに関与することで口腔扁平上皮癌細胞の基底膜浸潤を制御する可能性が示唆された. 研究成果の概要(英文): The degradation of extracellular matrix (ECM) is one of the most important processes in the invasion and metastasis of malignant tumor cells. Reptin gene, is known a component of the chromatin remodeling complex, is reported that repress the expression of the metastasis suppressor gene and hence repress the invasion and metastasis of malignant tumor cells. In this study, using two cell lines derived from human oral squamous cell carcinomas, OSC-19 and OSC-20, we demonstrated that knockdown of reptin gene promoted mobility, changed those cells shapes to spindle, and suppress the expression of E-cadherin, promoted the expression of N-cadherin. These phenomena is indicated that reptin regulate the invasiveness into the ECM with relation to EMT (epithelial-mesenchymal transition).","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目:基盤研究(C); 研究期間:2011~2013; 課題番号:23592952; 研究分野:医歯薬学; 科研費の分科・細目:歯学・外科系歯学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/70324796.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAKAHARA, Hirokazu"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 准教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中原, 寛和"},{"creatorName":"ナカハラ, ヒロカズ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"3991","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"70324796","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23592952seika.pdf","filesize":[{"value":"334.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23592952seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14010/files/KAKEN_23592952seika.pdf"},"version_id":"9b6fba4b-e35a-4ed4-b487-f0209e6c1c48"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"癌の浸潤・転移","subitem_subject_scheme":"Other"},{"subitem_subject":"上皮間葉移行","subitem_subject_scheme":"Other"},{"subitem_subject":"レプチン","subitem_subject_scheme":"Other"},{"subitem_subject":"扁平上皮癌","subitem_subject_scheme":"Other"},{"subitem_subject":"口腔癌","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"レプチン遺伝子による上皮間葉移行制御の分子機構","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レプチン遺伝子による上皮間葉移行制御の分子機構"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"14010","relation_version_is_last":true,"title":["レプチン遺伝子による上皮間葉移行制御の分子機構"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:04:59.389027+00:00"}