{"created":"2023-06-20T16:43:11.710917+00:00","id":14008,"links":{},"metadata":{"_buckets":{"deposit":"d9a7d3ec-bd05-4e5d-af86-9833ca766fe6"},"_deposit":{"created_by":3,"id":"14008","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14008"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014008","sets":["14:2667:2671:2672"]},"author_link":["25720","25719","25718"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The role of the interaction between integrin and TGF-beta in the eye wound healing"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 角膜線維芽細胞(keratocyte)はTGF-β刺激を受けると, 活性化し, 筋線維芽細胞様の形態を示すようになった. また, TGF-β処理によりkeratocyteのインテグリンα11(ITGA11), α-SMA, fibronectinの発現は亢進した. ITGA11およびcalcium- and integrin-binding protein 1（CIB1）を高発現させた細胞はTGF-βに対する感受性が亢進した. また, 緑茶成分epigallocatechin-3-gallate (EGCG)はTGF-βtype IIレセプターに結合し, TGF-βの作用を阻害することが判明した.           研究成果の概要（英文): When corneal fibroblast (keratocyte) was stimulated by TGF-beta, the keratocytes showed myofibroblast-like morphology. In addition, the expression of integrin alpha11 (ITGA11), alpha-smooth muscle actin (alpha-SMA), fibronectin in keratocytes was increased by TGF-beta treatment. Sensitivity to TGF-beta was up-regulated in the cells constitutively expressing ITGA11 or calcium-and integrin-binding protein 1. It was suggested that ITGA11 and CIB1 could be the target protein of the organ fibrosis treatment. Furthermore, we found that the green tea component epigallocatechin-3-gallate (EGCG) binds to TGF-beta type II receptor and inhibits the action of TGF-beta.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2011～2013;   課題番号：23592596;   研究分野：医歯薬学;   科研費の分科・細目：外科系臨床医学・眼科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/60230736.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/50399119.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/40460852.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YOSHIDA, Koji"},{"subitem_text_language":"en","subitem_text_value":"SUGIOKA, Koji"},{"subitem_text_language":"en","subitem_text_value":"HAGIHARA, Satoru"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 准教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"吉田,  浩二"},{"creatorName":"ヨシダ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"杉岡,  孝二"},{"creatorName":"スギオカ, コウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"萩原,  智"},{"creatorName":"ハギハラ, サトル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23592596seika.pdf","filesize":[{"value":"288.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23592596seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14008/files/KAKEN_23592596seika.pdf"},"version_id":"d8803e8e-34a7-45e3-9781-8cecd9fd0998"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"創傷治癒","subitem_subject_scheme":"Other"},{"subitem_subject":"インテグリン","subitem_subject_scheme":"Other"},{"subitem_subject":"線維芽細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"TGF-β","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"眼創傷治癒におけるＴＧＦ‐βとインテグリンの相互作用の役割解明とその応用","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"眼創傷治癒におけるＴＧＦ‐βとインテグリンの相互作用の役割解明とその応用"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"14008","relation_version_is_last":true,"title":["眼創傷治癒におけるＴＧＦ‐βとインテグリンの相互作用の役割解明とその応用"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:03.246097+00:00"}