{"created":"2023-06-20T16:43:11.579494+00:00","id":14005,"links":{},"metadata":{"_buckets":{"deposit":"d0b7687a-65b7-44ea-a285-3b76a78eb7e0"},"_deposit":{"created_by":3,"id":"14005","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14005"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014005","sets":["14:2667:2671:2672"]},"author_link":["25712","25711","25713","25714"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Peptide-cocktail vaccination for hepatocellular carcinoma"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): ゲノム解析により発見された肝癌において発現している新規癌抗原（WDRPUH, FOXM1, MELK, HJURP)由来HLA-A2402拘束性エピトープペプチドとアジュバントを混合した癌ワクチン療法を行った. 五人に施行し, 一人に腫瘍縮小効果を認め, 一人にSDと癌の進行が制御された. 一人に食道静脈瘤からと思われる出血grade2を認めたが, ワクチンの効果による出血ではないと判断した. また, 皮膚の硬結も認めた. grade２を超える有害事象は認めなかった.           研究成果の概要（英文): We performed the peptide-cocktail vaccination for hepatocellular carcinoma. The vaccine mixes an adjuvant with WDRPUH, FOXM1, MELK, HJURP-derived and HLA-A24-restricted epitope peptides. The vaccine was tried on five liver cancer patients till the present. One patient had reduction of the tumor. The other patient had SD. Although adverse events were skin induration and gastrointestinal bleeding, both were two or less grades.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2011～2013;   課題番号：23592000;   研究分野：医歯薬学;   科研費の分科・細目：外科学一般","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/90309302.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/30169239.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/70263374.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/60227725.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ISHIKAWA, Hajime"},{"subitem_text_language":"en","subitem_text_value":"OKUNO, Kiyotaka"},{"subitem_text_language":"en","subitem_text_value":"TAKEYAMA, Yoshifumi"},{"subitem_text_language":"en","subitem_text_value":"NAKAI, Takuya"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 准教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石川,  原"},{"creatorName":"イシカワ, ハジメ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25711","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"60227725","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"奥野,  清隆"},{"creatorName":"オクノ, キヨタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25712","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"竹山,  宜典"},{"creatorName":"タケヤマ, ヨシフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25713","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"中居,  卓也"},{"creatorName":"ナカイ, タクヤ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25714","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23592000seika.pdf","filesize":[{"value":"86.6 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23592000seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14005/files/KAKEN_23592000seika.pdf"},"version_id":"1fa3fcfd-ac73-4063-b864-858a94910df9"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"肝癌ワクチン治療","subitem_subject_scheme":"Other"},{"subitem_subject":"免疫治療","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"肝細胞癌に対するペプチドワクチンカクテル療法","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"肝細胞癌に対するペプチドワクチンカクテル療法"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"14005","relation_version_is_last":true,"title":["肝細胞癌に対するペプチドワクチンカクテル療法"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:09.117651+00:00"}