{"created":"2023-06-20T16:43:11.536549+00:00","id":14004,"links":{},"metadata":{"_buckets":{"deposit":"5c570eda-ea71-458f-99a7-7d447cb7e87b"},"_deposit":{"created_by":3,"id":"14004","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14004"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014004","sets":["14:2667:2671:2672"]},"author_link":["25710","25709","25707","25708"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regional glucose metabolic reduction in dementia with Lewy bodies is independent of amyloid deposition"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): アミロイドイメージングと糖代謝画像を用いてアルツハイマー病(AD)についで多いレビー小体型認知症(DLB)の病態につき検討した. DLB群では半数がアミロイド沈着陽性, 残り半数が陰性であったが, 糖代謝はアミロイド沈着に依存せずAD群と比較して後頭葉, 頭頂側頭連合野, 後部帯状回・楔前部で有意に低いことを確認した.           研究成果の概要（英文): The purpose of this study was to clarify whether regional hypometabolism is related to amyloid deposits in the dementia with Lewy bodies (DLB) brain. Methods: Ten consecutive subjects with DLB and 10 Alzheimer disease (AD) patients who underwent both PiB-PET and FDG-PET were included in this study. Regional standardized uptake value ratio (SUVR)s normalised to cerebellar cortices were calculated in the FDG and PiB PET images. Results: All AD patients and five DLB patients showed amyloid deposits (PiB positive). The parietotemporal and occipital metabolism in the DLB group were significantly lower than those in the AD group. In DLB patients, there were no differences in regional glucose metabolism between PiB positive and negative patients. Conclusions: In the DLB brain, decreased regional glucose metabolism is unrelated to amyloid deposits, although the hypometabolic area overlaps with the AD hypometabolic area.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2011～2013;   課題番号：23591804;   研究分野：臨床;   科研費の分科・細目：核医学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/50534103.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20252653.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20296700.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/70335339.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ISHII, Kazunari"},{"subitem_text_language":"en","subitem_text_value":"MURAKAMI, Takamichi"},{"subitem_text_language":"en","subitem_text_value":"OKADA, Masahiro"},{"subitem_text_language":"en","subitem_text_value":"KUMANO, Seishi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授近畿大学医学部; 教授近畿大学医学部; 講師近畿大学医学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"石井,  一成"},{"creatorName":"イシイ, カズナリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"村上,  卓道"},{"creatorName":"ムラカミ, タカミチ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"岡田,  真広"},{"creatorName":"オカダ, マサヒロ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"熊野,  正士"},{"creatorName":"クマノ, セイシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23591804seika.pdf","filesize":[{"value":"226.9 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23591804seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14004/files/KAKEN_23591804seika.pdf"},"version_id":"2e57932f-d429-4eaf-aa7c-89f3d14cebcb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"認知症","subitem_subject_scheme":"Other"},{"subitem_subject":"レビー小体型認知症","subitem_subject_scheme":"Other"},{"subitem_subject":"PET","subitem_subject_scheme":"Other"},{"subitem_subject":"アミロイド","subitem_subject_scheme":"Other"},{"subitem_subject":"糖代謝","subitem_subject_scheme":"Other"},{"subitem_subject":"脳","subitem_subject_scheme":"Other"},{"subitem_subject":"アルツハイマー病","subitem_subject_scheme":"Other"},{"subitem_subject":"パーキンソン病","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"レビー小体型認知症におけるアミロイド沈着, 糖代謝病態解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"レビー小体型認知症におけるアミロイド沈着, 糖代謝病態解明"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"14004","relation_version_is_last":true,"title":["レビー小体型認知症におけるアミロイド沈着, 糖代謝病態解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:10.848203+00:00"}