{"created":"2023-06-20T16:43:11.493530+00:00","id":14003,"links":{},"metadata":{"_buckets":{"deposit":"23fcf5f1-96e3-4c4d-a54d-82a313790868"},"_deposit":{"created_by":3,"id":"14003","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"14003"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00014003","sets":["14:2667:2671:2672"]},"author_link":["25704","25705","25706"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"The role of c—Myb and ABCG2/BCRP in the drug resistance of mature T-cell lymphomas"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 本研究において研究代表者は, 成熟T細胞リンパ腫での新規c-Myb標的遺伝子として薬物トランスポーターABCG2/BCRPを同定した. c-MybとABCG2/BCRPは, 成熟T細胞リンパ腫において共発現することが確認された. さらにABCG2/BCRP特異的阻害剤であるKo143は, ドキソルビシンのATLL細胞株に対する抗腫瘍活性を優位に促進した. これらの結果より, c-Myb-ABCG2/BCRP経路は成熟T細胞リンパ腫の抗がん剤耐性機構において重要な役割を果たすことが示唆された.           研究成果の概要（英文): Previously, we have shown that an AP-1 family member, FRA-2, is consistently expressed at high levels in Adult T-cell leukemia/lymphoma (ATLL) and up-regulates the expression of CCR4 as well as that of several proto-oncogenes such as c-Myb, MDM2, and BCL6. Here, we identified an ABC transporter, ABCG2/BCRP, as a target gene of c-Myb in mature T-cell lymphomas including ATLL and cutaneous T-cell lymphomas (CTCLs). We detected the transcripts and proteins of c-Myb and ABCG2/BCRP in ATLL cells. Furthermore, Ko143, a selective ABCG2/BCRP inhibitor, enhanced the antitumor activity of doxorubicin against ATLL cell lines. Taken together, our findings support the notion that the c-Myb-ABCG2/BCRP pathway plays a role in chemoresistance of mature T-cell lymphomas.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2011～2013;   課題番号：23591633;   研究分野：医歯薬学;   科研費の分科・細目：内科系臨床医学・皮膚科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/60319663.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/10166910.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/00448771.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"NAKAYAMA, Takashi"},{"subitem_text_language":"en","subitem_text_value":"YOSHIE, Osamu"},{"subitem_text_language":"en","subitem_text_value":"HIGUCHI, Tomonori"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"中山,  隆志"},{"creatorName":"ナカヤマ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"義江,  修"},{"creatorName":"ヨシエ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"樋口,   智紀"},{"creatorName":"ヒグチ, トモノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23591633seika.pdf","filesize":[{"value":"427.1 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23591633seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/14003/files/KAKEN_23591633seika.pdf"},"version_id":"3bf3ec7c-522e-49af-9295-258fff1e3480"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"皮膚腫瘍学","subitem_subject_scheme":"Other"},{"subitem_subject":"抗がん剤耐性","subitem_subject_scheme":"Other"},{"subitem_subject":"成人T細胞白血病","subitem_subject_scheme":"Other"},{"subitem_subject":"リンパ腫(ATLL)","subitem_subject_scheme":"Other"},{"subitem_subject":"皮膚T細胞リンパ腫(CTCL)","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"成熟T細胞リンパ腫でのc-MybとABCG2/BCRPによる抗癌剤耐性機序の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成熟T細胞リンパ腫でのc-MybとABCG2/BCRPによる抗癌剤耐性機序の解明"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-29"},"publish_date":"2014-09-29","publish_status":"0","recid":"14003","relation_version_is_last":true,"title":["成熟T細胞リンパ腫でのc-MybとABCG2/BCRPによる抗癌剤耐性機序の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:12.660294+00:00"}