{"created":"2023-06-20T16:43:10.978407+00:00","id":13994,"links":{},"metadata":{"_buckets":{"deposit":"62a792ef-ab2f-4760-9b67-c5fac807c53b"},"_deposit":{"created_by":3,"id":"13994","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13994"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013994","sets":["14:2667:2671:2672"]},"author_link":["25675","25674","25677","25676"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Study of natural resources improving the interaction between adipocytes and vascularendothelial cells"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"6","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文）: 肥満は脂肪細胞の油滴蓄積によって生じ, 動脈硬化症の増悪因子である. 動脈硬化症の進展には, 血管内皮細胞の遊走により引き起こされる血管新生が関わっている. また, 血管内皮細胞には血栓形成を防ぐ機能がある. 本研究では, 脂肪細胞と血管内皮細胞の相互作用に影響する天然資源物質を解析した. その結果, 黒豆の色素成分であるcyanidin-3-glucoside や腐植物質が脂肪細胞存在下における血管内皮細胞の遊走能を抑制して動脈硬化の進展を抑制するだけではなく, 血栓形成をも抑制することを明らかにした.           研究成果の概要（英文）: Obesity is caused by the accumulation of oil into adipocytes and the deterioration factor for atherosclerosis. Angiogenesis induced by the migration of vascular endothelial (VE) cells is involved in acceleration of atherosclerosis. On the other hand, VE cells contribute to prevention of thrombogenesis. In this study, the natural resources which affect the interaction between adipocytes and VE cells were investigated. As a result, it was clarified that cyanidin-3-glucoside, natural pigments from black soy beans, and the humic substance inhibited the migration of VE cells in the presence of adipocytes. Moreover, it was demonstrated that the humic substance suppressed the progression of atherosclerosis and induced anti-thrombotic effect in animal model.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2011～2013;   課題番号：23590291;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・環境生理学（含体力医学・栄養生理学）","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/30193791.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/40030879.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20185432.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"https://kaken.nii.ac.jp/d/r/90510876.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"},{"subitem_text_value":"連携研究者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"UESHIMA, Shigeru"},{"subitem_text_language":"en","subitem_text_value":"MATSUO, Osamu"},{"subitem_text_language":"en","subitem_text_value":"OKADA, Kiyotaka"},{"subitem_text_language":"en","subitem_text_value":"YAMASHITA, Rina"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学農学部; 教授"},{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学農学部; 助手"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"上嶋,  繁"},{"creatorName":"ウエシマ, シゲル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25674","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"90510876","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"松尾,  理"},{"creatorName":"マツオ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25675","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡田,  清孝"},{"creatorName":"オカダ, キヨタカ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25676","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山下,  里奈"},{"creatorName":"ヤマシタ, リナ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25677","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23590291seika.pdf","filesize":[{"value":"474.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23590291seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13994/files/KAKEN_23590291seika.pdf"},"version_id":"ec697c49-5c0d-4d53-9a61-c4e00ce877e2"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"脂肪細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"血管内皮細胞","subitem_subject_scheme":"Other"},{"subitem_subject":"遊走","subitem_subject_scheme":"Other"},{"subitem_subject":"動脈硬化","subitem_subject_scheme":"Other"},{"subitem_subject":"肥満","subitem_subject_scheme":"Other"},{"subitem_subject":"天然資源物質","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脂肪細胞と血管内皮細胞の相互作用を改善する天然資源物質の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脂肪細胞と血管内皮細胞の相互作用を改善する天然資源物質の解析"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-04"},"publish_date":"2014-10-04","publish_status":"0","recid":"13994","relation_version_is_last":true,"title":["脂肪細胞と血管内皮細胞の相互作用を改善する天然資源物質の解析"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:31.305382+00:00"}