{"created":"2023-06-20T16:43:10.935757+00:00","id":13993,"links":{},"metadata":{"_buckets":{"deposit":"476bf238-70fc-411f-b653-bc8fd24747a3"},"_deposit":{"created_by":3,"id":"13993","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13993"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013993","sets":["14:2667:2671:2672"]},"author_link":["25671","25672","25673","25670"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regional and intercellular mechanism of oscillator synchrony in the mammalian circadian center."}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 視交叉上核発振細胞間の同期機構と位相波現象の機序の解明を目指した. 視交叉上核の腹側部と背側部にて包括的遺伝子発現解析を行った. その結果, 腹側ではVip遺伝子が背内側部ではVpac2遺伝子が最も特異性が高く, またおのおのの局在を形態学的に確認した. これはVIP/VPAC2受容体の視交叉上核内部における同期維持に対する重要性が示唆する. 一方でラット視交叉上核のスライス培養を用いForskolinを加えて細胞間同期を破壊することができた. それによって異なる固有周期を持つ２領域を視交叉上核背内側部でつきとめることができた. さらに数値的シミュレーションにてこの領域周期差が位相波を作ることが示唆された.           研究成果の概要（英文): We have investigated what systems maintain the synchrony in the SCN. We performed a microarray study to investigate the genes intrinsically expressed in dorsal and ventral region of the suprachiasmatic nucleus (SCN) and found that Vip gene and Vpac2 genes were specifically expressed in the DMS CN and VLSCN, respectively. This suggests that the synchrony among SCN oscillators depends on the VIP/VPAC2 receptor system. Then, we artificially disrupted the intercellular coupling among oscillating neurons in the SCN. The analysis divided the SCN into two regions: a medial region with periods shorter than 24 h (short period region, SPR) and another lateral region with periods longer than 24 h (long period region, LPR ). Further, a mathematical model of the SCN based on the results faithfully reproduced the kinetics of the oscillators in the SCN. The findings suggest that the regional period difference in the SCN generates the phase","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2011～2013;   課題番号：23590290;   研究分野：医歯薬学;   科研費の分科・細目：基礎医学・環境生理学（含体力医学・栄養生理学）","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20275192.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/10340770.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/30460843.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/60580529.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SHIGEYOSHI, Yasufumi"},{"subitem_text_language":"en","subitem_text_value":"KOINUMA, Satoshi"},{"subitem_text_language":"en","subitem_text_value":"SUJINO, Mitsugu"},{"subitem_text_language":"en","subitem_text_value":"MASUMOTO, Kohei"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部; 助教"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"重吉,  康史"},{"creatorName":"シゲヨシ, ヤスフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"鯉沼,  聡"},{"creatorName":"コイヌマ, サトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"筋野,  貢"},{"creatorName":"スジノ, ミツグ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"升本,  宏平"},{"creatorName":"マスモト, コウヘイ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23590290seika.pdf","filesize":[{"value":"166.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23590290seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13993/files/KAKEN_23590290seika.pdf"},"version_id":"e65a1dfa-5290-4471-b972-66e8232cd470"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"視交叉上核","subitem_subject_scheme":"Other"},{"subitem_subject":"概日リズム","subitem_subject_scheme":"Other"},{"subitem_subject":"同期","subitem_subject_scheme":"Other"},{"subitem_subject":"日長","subitem_subject_scheme":"Other"},{"subitem_subject":"光周性","subitem_subject_scheme":"Other"},{"subitem_subject":"Per1","subitem_subject_scheme":"Other"},{"subitem_subject":"時計遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"Forskolin","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"哺乳類体内時計中枢の領域間および細胞間同期--構造多様性をふまえて","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"哺乳類体内時計中枢の領域間および細胞間同期--構造多様性をふまえて"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"13993","relation_version_is_last":true,"title":["哺乳類体内時計中枢の領域間および細胞間同期--構造多様性をふまえて"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:33.057648+00:00"}