{"created":"2023-06-20T16:43:10.763464+00:00","id":13989,"links":{},"metadata":{"_buckets":{"deposit":"f4839afd-b5ba-48cd-b3a9-e73f0896cbfb"},"_deposit":{"created_by":3,"id":"13989","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13989"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013989","sets":["14:2667:2671:2672"]},"author_link":["25660","25661"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of novel pro-drugs based on the bile acid as a core compound"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文): ウルソデオキシコール酸のN-アセチルシステイン抱合体(UDCA-NAC)が、肝で硫酸抱合を受ける一方, NACが加水分解されてUDCAとして体内を循環することを明らかにした. さらに, UDCA-NACはアセトアミノフェン誘発肝障害ラットの肝疾患マーカー酵素の上昇を抑制することを示した. これらの知見は, UDCA-NACが新規肝・胆・消化機能改善薬のプロドラッグとして有用であることを示している.           研究成果の概要(英文) : We demonstrated that N-acetylcysteine conjugate of ursodeoxycholic acid (UDCA-NAC) was hydrolyzed and circulated in body as UDCA after administration by injection via jugular vein, while UDCA-NAC converted to NAC-sulfate di-conjugate by rat liver cytosolic fraction. Furthermore, UDCA-NAC was shown to inhibit the increase of liver disease marker enzymes, AST and ALT, in serum of acetaminophen-induced liver injury rats. These results showed that UDCA-NAC is useful as a prodrug of the new liver, bile, digestive function improving agent.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2011～2013;   課題番号：23590209;   研究分野：医歯薬学 ;   科研費の分科・細目：薬学・医療系薬学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/70242526.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/90111301.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"MITAMURA, Kuniko"},{"subitem_text_language":"en","subitem_text_value":"IKEGAWA, Shigeo"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 准教授"},{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"三田村,  邦子"},{"creatorName":"ミタムラ, クニコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"池川,  繁男"},{"creatorName":"イケガワ, シゲオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23590209seika.pdf","filesize":[{"value":"159.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23590209seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13989/files/KAKEN_23590209seika.pdf"},"version_id":"57e5df0e-6780-4ff0-b2b8-056f53f09066"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"胆汁酸","subitem_subject_scheme":"Other"},{"subitem_subject":"N-アセチルシステイン","subitem_subject_scheme":"Other"},{"subitem_subject":"プロドラッグ","subitem_subject_scheme":"Other"},{"subitem_subject":"肝・胆・消化機能改善薬","subitem_subject_scheme":"Other"},{"subitem_subject":"液体クロマトグラフィー","subitem_subject_scheme":"Other"},{"subitem_subject":"質量分析法","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胆汁酸を核化合物とする新規プロドラッグの創製","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胆汁酸を核化合物とする新規プロドラッグの創製"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-29"},"publish_date":"2014-09-29","publish_status":"0","recid":"13989","relation_version_is_last":true,"title":["胆汁酸を核化合物とする新規プロドラッグの創製"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:39.342127+00:00"}