{"created":"2023-06-20T16:43:10.721407+00:00","id":13988,"links":{},"metadata":{"_buckets":{"deposit":"96cd6468-47aa-4095-9105-9390fe3c6137"},"_deposit":{"created_by":3,"id":"13988","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13988"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013988","sets":["14:2667:2671:2672"]},"author_link":["25658","25659"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Development of the effective ophthalmic formulations that simultaneously targeting intraocular  pressure and optic nerve"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): L-ピログルタミン酸は一酸化窒素を抑制することで, 眼房水産生及び眼圧低下作用を有すること, また, これらL-ピログルタミン酸は, 視神経賦活効果も有していることを明らかとした. さらに, 点眼製剤より高濃度の薬物供給が可能である眼瞼適用ゲルパッチを開発した. 以上, L-ピログルタミン酸と眼瞼適用ゲルパッチを用いることで, 眼圧降下と視神経保護を同時標的とした新しい緑内障治療薬の開発に繋がる可能性を示した. 研究成果の概要（英文): We demonstrated that the treatment of L-pyroglutamic acid decreased the enhanced intraocular pressure, and enhanced the survival of retinal ganglion cells after optic nerve transection in the in vivo study. In addition, we tried to develop the transdermal drug delivery system for ophthalmic therapy. It is possible that the transdermal ophthalmic therapy by using L-pyroglutamic acid provide the effective therapy for glaucoma patient.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2011～2013;   課題番号：23590208;   研究分野：医歯薬学;   科研費の分科・細目：衛生学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/50128633.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/90411579.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"連携研究者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ITO, Yoshimasa"},{"subitem_text_language":"en","subitem_text_value":"NAGAI,  Noriaki"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 准教授"},{"subitem_text_value":"近畿大学薬学部; 講師"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤,  吉將"},{"creatorName":"イトウ, ヨシマサ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"長井,  紀章"},{"creatorName":"ナガイ, ノリアキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23590208seika.pdf","filesize":[{"value":"580.2 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23590208seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13988/files/KAKEN_23590208seika.pdf"},"version_id":"6f566344-057a-4304-8841-b8aa8a37c842"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"ピログルタミン酸","subitem_subject_scheme":"Other"},{"subitem_subject":"緑内障","subitem_subject_scheme":"Other"},{"subitem_subject":"シクロデキストリン","subitem_subject_scheme":"Other"},{"subitem_subject":"眼圧","subitem_subject_scheme":"Other"},{"subitem_subject":"視神経","subitem_subject_scheme":"Other"},{"subitem_subject":"一酸化窒素","subitem_subject_scheme":"Other"},{"subitem_subject":"眼瞼適用ゲルパッチ","subitem_subject_scheme":"Other"},{"subitem_subject":"網膜","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"眼圧降下と視神経保護を同時標的とした新しい緑内障治療薬の開発","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"眼圧降下と視神経保護を同時標的とした新しい緑内障治療薬の開発"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-29"},"publish_date":"2014-09-29","publish_status":"0","recid":"13988","relation_version_is_last":true,"title":["眼圧降下と視神経保護を同時標的とした新しい緑内障治療薬の開発"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:41.507612+00:00"}