{"created":"2023-06-20T16:43:10.636052+00:00","id":13986,"links":{},"metadata":{"_buckets":{"deposit":"ae0a8ded-04dc-4eb3-b5a6-703485d49ab3"},"_deposit":{"created_by":3,"id":"13986","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13986"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013986","sets":["14:2667:2671:2672"]},"author_link":["25655","25654"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Study of roles of endogenous hydrogen sulfide in stomach with mucosal injury"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要(和文): ヒト胃癌由来AGS細胞において, 生体内で硫化水素(H2S)産生に関わる酵素の1つであるcystathionine-gamma-lyase(CSE)により産生された内因性H2Sは, AGS細胞の増殖を促進的に調節していることが示唆された. この効果の一部には, H2SによるCav3.2T型カルシウムチャネルの機能増強およびNF-kappaB系の活性化を介した抗アポトーシスタンパクBcl-2とBcl-xLの発現増加が関与している可能性が示唆された. これらの経路は胃癌治療の新たなターゲットとなることが期待される.           研究成果の概要(英文): In human gastric cancer-derived AGS cells, our findings suggest that endogenous hydrogen sulfide (H2S) produced by cystathionine-gamma-lyase (CSE), one of H2S-forming enzymes in the mammalian body, accelerates the proliferation of AGS cells. The effects of H2S may be mediated, in part, by increase in function of Cav3.2 T-type calcium channels and upregulation of anti-apoptotic proteins, Bcl-2 and Bcl-xL, via activation of NF-kappaB caused by endogenous H2S. These pathways can be expected to be effectivetargets for treatment of gastric cancer.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究（C）;  研究期間：2011～2013;   課題番号：23590122;   研究分野：医歯薬学;   科研費の分科・細目：生物系薬学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/90271410.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20177728.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"SEKIGUCHI, Fumiko"},{"subitem_text_language":"en","subitem_text_value":"KAWABATA, Atsufumi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学薬学部; 准教授"},{"subitem_text_value":"近畿大学薬学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"関ロ,  富美子"},{"creatorName":"セキグチ, フミコ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25654","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"20177728","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"川畑,  篤史"},{"creatorName":"カワバタ, アツフミ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25655","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23590122seika.pdf","filesize":[{"value":"897.5 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23590122seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13986/files/KAKEN_23590122seika.pdf"},"version_id":"ffce122a-3d76-4c87-bcbd-36773d07b7aa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"硫化水素合成酵素","subitem_subject_scheme":"Other"},{"subitem_subject":"胃癌細胞増殖","subitem_subject_scheme":"Other"},{"subitem_subject":"T型カルシウムチャネル","subitem_subject_scheme":"Other"},{"subitem_subject":"抗アポトーシス因子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"胃粘膜傷害時における内因性硫化水素の挙動と生理的役割に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"胃粘膜傷害時における内因性硫化水素の挙動と生理的役割に関する研究"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-09-29"},"publish_date":"2014-09-29","publish_status":"0","recid":"13986","relation_version_is_last":true,"title":["胃粘膜傷害時における内因性硫化水素の挙動と生理的役割に関する研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:45.673446+00:00"}