{"created":"2023-06-20T16:43:10.336748+00:00","id":13979,"links":{},"metadata":{"_buckets":{"deposit":"54e32801-b390-44d9-a010-24b1c579ff0f"},"_deposit":{"created_by":3,"id":"13979","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13979"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013979","sets":["14:2667:2671:2672"]},"author_link":["25651","25649","25650"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Elucidation of the mechanism of onset of steatohepatitis and prevention of pathogenesis with the food ingredients by targeting Nrf2"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"4","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 非アルコール性脂肪肝炎の発症機序の一因として酸化ストレス防御遺伝子群制御転写因子Nrf2に着目し, Nrf2欠損型マウスの解析からNrf2と脂肪肝炎の発症との関連性が示唆された. ワサビの成分でNrf2のアクチベーターである6-メチルスルフィニルヘキシルイソチオシアネートを投与したところ野生型マウスで脂肪肝の改善を認め, 欠損型マウスで改善を認めなかったことよりNrf2を標的とした脂肪肝炎の予防や治療の可能性が明らかとなった.           研究成果の概要（英文): Oxidative stress has been implicated in the transition from simple hepatic steatos is to nonalcoholic steatohepatitis (NASH). The Nuclear factor E2-related factor 2 (Nrf2) transcription factor serves as a cellular sensor for oxidative and electrophilic stress. Nrf2 deletion dysregulates hepatic mRNA expression of lipid and iron metabolism related genes and tends to increase hepatic triglycerides and iron, suggesting that Nrf2 may play a role in the pathogenesis of NASH. Wasabi derivative 6-methylsulfinylhexyl isothiocyanate, a potent Nrf2 activator, prevented the fatty liver produced by a high-fat diet in mice. These data indicated that Nrf2 could prevent the onset and progression of steatohepatitis.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2011～2013;   課題番号：23580188;   研究分野：農学;   科研費の分科・細目：農芸化学・食品科学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/00465650.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/20233934.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/00133546.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究協力者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"TANAKA, Yuji"},{"subitem_text_language":"en","subitem_text_value":"KAMISAKO, Toshinori"},{"subitem_text_language":"en","subitem_text_value":"OGAWA, Hiroshi"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部附属病院; 講師"},{"subitem_text_value":"近畿大学医学部附属病院; 教授"},{"subitem_text_value":"帝塚山学院大学人間科学部; 教授"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中,  裕滋"},{"creatorName":"タナカ, ユウジ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"上硲,  俊法"},{"creatorName":"カミサコ, トシノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"小川,  博"},{"creatorName":"オガワ, ヒロシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23580188seika.pdf","filesize":[{"value":"95.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23580188seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13979/files/KAKEN_23580188seika.pdf"},"version_id":"68f54c1d-7d72-4867-bda6-efdf0b397daa"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Nrf2","subitem_subject_scheme":"Other"},{"subitem_subject":"酸化ストレス","subitem_subject_scheme":"Other"},{"subitem_subject":"脂肪肝炎","subitem_subject_scheme":"Other"},{"subitem_subject":"食品機能","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"酸化ストレス制御転写因子を標的とした脂肪肝炎の発症機構の解明と食品成分による予防","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"酸化ストレス制御転写因子を標的とした脂肪肝炎の発症機構の解明と食品成分による予防"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"13979","relation_version_is_last":true,"title":["酸化ストレス制御転写因子を標的とした脂肪肝炎の発症機構の解明と食品成分による予防"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:05:59.418140+00:00"}