{"created":"2023-06-20T16:43:09.203928+00:00","id":13953,"links":{},"metadata":{"_buckets":{"deposit":"981f4470-836b-42fe-98a9-ddc0fc94bcff"},"_deposit":{"created_by":3,"id":"13953","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13953"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013953","sets":["14:2667:2671:2672"]},"author_link":["25616","25615","25614"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Transcriptional regulation of CCR7 expression in mature T-cell malignancies"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): 我々は, 成人T細胞白血病/リンパ腫（ATL）でのCCR4発現に関わる転写因子としてAP-1ファミリーのFRA-2を同定し, FRA-2はJUNDと共同してATLの増殖を促進するとともにc-Myb, SOX4などの原癌遺伝子の発現を誘導することを明らかにした. 本研究では, ATLおよび皮膚T細胞リンパ腫（CTCL）でのCCR7発現に関与する転写因子を検討し, 新規DNA結合配列GAGGAGを同定し, その部位にはZFYVE19が結合することを明らかにした. 本研究から, ATLやCTCLでの新たな発がん遺伝子カスケードの存在が示唆され、これらの成熟型T細胞性腫瘍の診断や治療に有用な情報が提供された.           研究成果の概要（英文): Previously, we have examined the transcriptional regulation of CCR4 expression in adult T-cell leukemia/lymphoma (ATL) and demonstrated that an AP-1 family member FRA-2 is aberrantly expressed in ATL and in association with JUND promotes CCR4 expression and cell growth together with up regulation of various proto-oncogenes such as c-Myb and SOX4 in ATL. In the present study, we have extended our analysis to CCR7, which is highly expressed in ATL and cutaneous T cell lymphomas (CTCLs), and found a novel DNA-binding element GAGGAG in the CCR7 promoter and binding of ZFYVE19 to this element. Our study suggests an existence of another oncogenic cascade in ATL and CTCLs, providing useful information on the diagnosis and treatment of mature T cell malignancies.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2011 ～ 2013;   課題番号：23501273;   研究分野：総合領域;   科研費の分科・細目：腫瘍学・腫瘍生物学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/10166910.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/60319663.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/00448771.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"YOSHIE, Osamu"},{"subitem_text_language":"en","subitem_text_value":"NAKAYAMA, Takashi"},{"subitem_text_language":"en","subitem_text_value":"HIGUCHI, Tomonori"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 教授"},{"subitem_text_value":"近畿大学薬学部; 教授"},{"subitem_text_value":"近畿大学医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"義江,  修"},{"creatorName":"ヨシエ, オサム","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{},{}]},{"creatorNames":[{"creatorName":"中山,  隆志"},{"creatorName":"ナカヤマ, タカシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"樋口,  智紀"},{"creatorName":"ヒグチ, トモノリ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23501273seika.pdf","filesize":[{"value":"269.3 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23501273seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13953/files/KAKEN_23501273seika.pdf"},"version_id":"543ed72a-f659-4a1a-8153-8715048acf14"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"CCR7","subitem_subject_scheme":"Other"},{"subitem_subject":"ケモカイン","subitem_subject_scheme":"Other"},{"subitem_subject":"転写因子","subitem_subject_scheme":"Other"},{"subitem_subject":"成人T細胞白血病／リンパ腫（ATL）","subitem_subject_scheme":"Other"},{"subitem_subject":"皮膚T細胞リンパ腫（CTCL）","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"成熟Ｔ細胞腫瘍で強く発現するケモカイン受容体ＣＣＲ７の発現制御機構の解明","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"成熟Ｔ細胞腫瘍で強く発現するケモカイン受容体ＣＣＲ７の発現制御機構の解明"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"13953","relation_version_is_last":true,"title":["成熟Ｔ細胞腫瘍で強く発現するケモカイン受容体ＣＣＲ７の発現制御機構の解明"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:06:44.180689+00:00"}