@techreport{oai:kindai.repo.nii.ac.jp:00013951,
 author = {丹羽,  淳子 and 髙橋,  英夫 and 早坂,  直人},
 month = {Jan},
 note = {研究成果の概要（和文): 成体脳の神経幹細胞分化の条件は極めて難しい. 運動療法（習慣）の有効性を受け, それを決定する要因として(1)神経幹(前駆）細胞自体の生存と活性, (2)幹（前駆）細胞の成長や分化に関与する炎症性分子や神経栄養因子などの脳内微小環境, (3)傷害後の時間的因子を考え, 重症高血圧と脳卒中自然発症性のラットに長期の自発運動をさせ検討した. 生存率の延長, 神経機能改善は発症後2日目から運動を開始したラットにも認められた. 運動により骨髄細胞老化が抑制され, 内在性神経幹(前駆）細胞の増加と成長分化が促進された. 全身性及び脳局所の炎症反応が抑制され, 血管内皮細胞由来NO産生と傷害後早期に神経栄養因子が誘導された.           研究成果の概要（英文): Long-term voluntary exercise (EX) decreased stroke events in stroke-prone genetically hypertensive rats (SHRSP). Volume of cerebral lesion was also reduced and neural defects were improved, resulting in prolonged life span in post-stroke EX rats. Possible strategies for regenerating damaged central nervous system;(1)activation of endogenous neural stem (progenitor) cells (NSC) (2)modification of microenvironment surrounding stroke lesion for their development and differentiation (3)enhanced migration of endothelial progenitor cells (EPC) and NSC. We found that Ex increased the number of NSC and EPC, and enhaced their differentiation in lateral venticle and cerebral lesion. Cell senescence in bone marrow was suppressed by EX. Production of inflammatory factors in plasma, CSF and lesion was also decreased in EX rats. The improvement may depend on NO production. Nerve growth factors and chemokine including BDNF, FGF, EGF, IGF-1 and CXCL12 were produced in early phase after stroke in EX., 研究種目： 基盤研究(C); 研究期間：2011～2013;   課題番号：23500866;   研究分野：総合領域;   科研費の分科・細目：健康・スポーツ科学・応用健康科学, application/pdf},
 title = {運動習慣による脳血管再生環境の構築},
 year = {2013},
 yomi = {ニワ, アツコ and タカハシ, ヒデオ and ハヤサカ, ナオト}
}