{"created":"2023-06-20T16:43:09.069472+00:00","id":13950,"links":{},"metadata":{"_buckets":{"deposit":"980a7d9b-2993-481f-99a0-ed65e7711b6a"},"_deposit":{"created_by":3,"id":"13950","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"13950"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00013950","sets":["14:2667:2671:2672"]},"author_link":["25609","25608","25610"],"item_8_alternative_title_3":{"attribute_name":"その他（別言語等）のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury"}]},"item_8_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2013-01-01","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"5","bibliographicPageStart":"1","bibliographic_titles":[{"bibliographic_title":"科学研究費助成事業研究成果報告書 (2013. )"}]}]},"item_8_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"研究成果の概要（和文): ラット脳外傷モデルを用いて運動による神経保護作用を調べた. 脳外傷後の早期に損傷部位周囲でssDNA陽性細胞数は運動群では非運動群に比較し有意な減少を認めた. 非運動群では多数のssDNAとNeuNの二重染色陽性細胞が多数であったが運動群では少数であった. 外傷後の慢性期において運動群で非運動群に比較しNeuN陽性細胞数で有意な増加を認めた. 外傷後の脳機能評価において運動群で有意な改善効果が認められた. 運動は脳外傷後に神経保護作用を有することが示された. 加えて, 脳外傷後に起こる脳機能不全を運動は有意に改善する. 脳外傷における脳機能不全の治療においても運動は非常に有効であることが示された.           研究成果の概要（英文): we investigate the effect of exercise on morphology and cerebral function following TBI in rats. Wistar rats received TBI by a pneumatic controlled injury device and were randomly divided into two groups: 1) non-exercise group and 2) exercise group. The exercise group ran on a treadmill. Immunohistochemical and behavioral studies were performed following TBI. The number of ssDNA-positive cells early after TBI was significantly reduced in the exercise group. Furthermore, most ssDNA-positive cells in the non-exercise group co-localized with neuronal cells. However, in the exercise group, few ssDNA-positive cells co-localized. In addition, there was a significant increase in neuronal cell number and improvement in cerebral dysfunction after TBI in the exercise group. These results indicate that exercise following TBI inhibits neuronal apoptotic cell death, which results in an improvement of cerebral dysfunction.","subitem_description_type":"Abstract"}]},"item_8_description_36":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"研究種目：基盤研究(C);  研究期間：2011～2013;   課題番号：23500629;   研究分野：総合領域;   科研費の分科・細目：人間医工学","subitem_description_type":"Other"}]},"item_8_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Research Paper","subitem_description_type":"Other"}]},"item_8_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_8_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"近畿大学"}]},"item_8_relation_11":{"attribute_name":"著者 外部リンク","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/40330245.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/70162443.ja.html"}]},{"subitem_relation_name":[{"subitem_relation_name_text":"http://kaken.nii.ac.jp/d/r/00441006.ja.html"}]}]},"item_8_text_10":{"attribute_name":"著者 役割","attribute_value_mlt":[{"subitem_text_value":"研究代表者"},{"subitem_text_value":"研究分担者"},{"subitem_text_value":"研究分担者"}]},"item_8_text_7":{"attribute_name":"著者(英)","attribute_value_mlt":[{"subitem_text_language":"en","subitem_text_value":"ITOH, Tatsuki"},{"subitem_text_language":"en","subitem_text_value":"SATOU, Takao"},{"subitem_text_language":"en","subitem_text_value":"INOUE, Takao"}]},"item_8_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"近畿大学医学部; 講師"},{"subitem_text_value":"近畿大学医学部附属病院・教授"},{"subitem_text_value":"近畿大学・医学部; 助教"}]},"item_8_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"伊藤,  龍生"},{"creatorName":"イトウ, タツキ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25608","nameIdentifierScheme":"WEKO"},{"nameIdentifier":"00441006","nameIdentifierScheme":"研究者番号","nameIdentifierURI":" "}]},{"creatorNames":[{"creatorName":"佐藤,  隆夫"},{"creatorName":"サトウ, タカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25609","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上,  敬夫"},{"creatorName":"イノウエ, タカオ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"25610","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-03-31"}],"displaytype":"detail","filename":"KAKEN_23500629seika.pdf","filesize":[{"value":"383.0 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KAKEN_23500629seika.pdf","url":"https://kindai.repo.nii.ac.jp/record/13950/files/KAKEN_23500629seika.pdf"},"version_id":"fc8765f2-7cb6-4af2-a23d-0b925bd677b1"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"リハビリテーション","subitem_subject_scheme":"Other"},{"subitem_subject":"神経再生","subitem_subject_scheme":"Other"},{"subitem_subject":"運動","subitem_subject_scheme":"Other"},{"subitem_subject":"脳外傷","subitem_subject_scheme":"Other"},{"subitem_subject":"高次脳機能改善","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"脳外傷後の長期間運動による神経再生促進効果の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"脳外傷後の長期間運動による神経再生促進効果の研究"}]},"item_type_id":"8","owner":"3","path":["2672"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-10-16"},"publish_date":"2014-10-16","publish_status":"0","recid":"13950","relation_version_is_last":true,"title":["脳外傷後の長期間運動による神経再生促進効果の研究"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2023-06-20T23:06:48.823307+00:00"}