@article{oai:kindai.repo.nii.ac.jp:00011623,
 author = {新貝, 恭広 and Shinkai, Yasuhiro and 柏原, 慎一 and Kashihara, Shinichi and 藤井, 政幸 and Fujii, Masayuki},
 issue = {23},
 journal = {かやのもり：近畿大学産業理工学部研究報告, Reports of Faculty of Humanity-Oriented Science and Engineering, Kinki University},
 month = {Dec},
 note = {In the present study, we investigated the intracellular delivery of siRNA using synthetic peptides as transfection reagents and the silencing effect of siRNA targeting hTERT mRNA in 3 human cancer cell lines, Jurkat, HeLa and K562. The complex of siRNA and a specific amphiphilic peptide could be effectively taken up into  cells. The complex also showed a high silencing effect against hTERT mRNA. Moreover, the combination of siRNA-NES conjugates and the amphiphilic peptides improved silencing effects up to 95.2%. The amphiphilic peptides and their hybrids showed almost no cyto-toxicity and protected siRNA against intracellular nuclease digestion in 10% FBS (half life time was over 48h)., application/pdf},
 pages = {1--4},
 title = {〈論文・報告〉新規合成ペプチドによるsiRNAの無毒性細胞導入と遺伝子サイレンシング},
 year = {2015},
 yomi = {シンカイ, ヤスヒロ and カシハラ, シンイチ and フジイ, マサユキ}
}