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Distinct cytoskeletal mechanisms in the maintenance of lysophosphatidic acid-produced retracted neurites in young cortical neurons
https://kindai.repo.nii.ac.jp/records/11065
https://kindai.repo.nii.ac.jp/records/110652133efac-cbfc-4a8e-abaa-c1f9b2730a7f
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
AN10074306-20100228-0015.pdf (1.8 MB)
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| Item type | ☆紀要論文 / Departmental Bulletin Paper(1) | |||||||||
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| 公開日 | 2010-08-05 | |||||||||
| タイトル | ||||||||||
| タイトル | Distinct cytoskeletal mechanisms in the maintenance of lysophosphatidic acid-produced retracted neurites in young cortical neurons | |||||||||
| 言語 | en | |||||||||
| 著者 |
Fukushima, Nobuyuki
× Fukushima, Nobuyuki
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| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | LPA, actin, tubulin, neurofilament, Rho, Rho-kinase, myosin | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | departmental bulletin paper | |||||||||
| 著者(英) | ||||||||||
| 言語 | en | |||||||||
| 値 | 福嶋, 伸之 | |||||||||
| 著者 所属 | ||||||||||
| 値 | RIST, Kinki University | |||||||||
| 版 | ||||||||||
| 出版タイプ | NA | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_be7fb7dd8ff6fe43 | |||||||||
| 出版者 名前 | ||||||||||
| 出版者 | 近畿大学理工学総合研究所 | |||||||||
| 書誌情報 |
理工学総合研究所研究報告 en : Annual reports by Research Institute for Science and Technology 号 22, p. 15-21, 発行日 2010-02-01 |
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| ISSN | ||||||||||
| 収録物識別子タイプ | ISSN | |||||||||
| 収録物識別子 | 09162054 | |||||||||
| 抄録 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | Young cortical neurons respond to a bioactive lipid lysophosphatidic acid (LPA) with not only neurite retraction but also actin microspike cap formation and collapse of non-actin components. These responses require the small GTPase Rho-dependent actin polymerization. However, when neurite retraction is completed, how rearranged cytoskeletal components are maintained for the retraction period remains unclear. Here I pharmacologically investigated the signaling mechanisms for the maintenance of rearranged cytoskeletal components. Actin caps disappeared when inhibitors for Rho and actomyosin pathways were added to neurons having actin microspikes induced by LPA. By contrast, these inhibitors failed to affect the maintenance of collapsed non-actin cytoskeleton. These results implicate distinct cytoskeletal mechanisms in the maintenance of retracted neurites induced by LPA. | |||||||||
| フォーマット | ||||||||||
| 内容記述タイプ | Other | |||||||||
| 内容記述 | application/pdf | |||||||||
