| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2015-07-31 |
| タイトル |
|
|
タイトル |
<Originals> Interleukin-18 receptor α has differing roles in the systemic response and renal inflammation in lipopolysaccharide-induced acute kidney injury |
|
言語 |
en |
| 著者 |
Hino, Shoichi
Nozaki, Yuji
Nagare, Yasuaki
Kinoshita, Koji
Funauchi, Masanori
Matsumura, Itaru
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
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主題 |
Acute kidney injury, Lipopolysaccharide, Cytokines |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine |
| 著者 所属 |
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|
値 |
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine |
| 著者 所属 |
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|
値 |
Department of Rheumatology, Sakai Hospital, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Hematology and Rheumatology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
近畿大学 |
| 著者所属(翻訳) |
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|
値 |
近畿大学 |
| 著者所属(翻訳) |
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|
値 |
近畿大学 |
| 著者所属(翻訳) |
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値 |
近畿大学 |
| 著者所属(翻訳) |
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|
値 |
近畿大学 |
| 著者所属(翻訳) |
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|
値 |
近畿大学 |
| 版 |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
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出版者 |
Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 40,
号 1,
p. 15-22,
発行日 2015-06-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
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内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Interleukin (IL)-18 has important roles in the pathogenesis of organ failure caused by endotoxemia. To determine whether IL-18 receptor(R)αsignaling ameliorates or deteriorates the renal function in lipopolysaccharide (LPS)-induced acute kidney injury(AKI), we compared IL-18Rα knockout (KO) mice with wild-type (WT) mice following LPS injection. As the results, IL-18Rα deficiency ameliorated the renal function and reduced the serum level of pro-inflammatory cytokines, such as tumor necrosis factor (TNF), interferon-gamma (IFN-γ), and IL-18. The renal suppressor of cytokine signaling 1(SOCS1) mRNA expression was also significantly reduced in IL-18Rα KO mice compared with WT mice. In addition, the adoptivetransfer of splenocytes from WT mice into IL-18Rα KO mice increased their serum pro-inflammatory cytokine levels and deteriorated the renal function In conclusion, IL-18Rα deficiency ameliorated the release of systemic pro-inflammatory cytokines and renal function in mice with LPS-induced AKI. Thus, IL-18Rα affects renal injury through the pro-inflammatory cytokine signaling pathway in the pathogenesis of LPS-induced AKI. |
| フォーマット |
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|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20150600-0015.pdf (504.1 kB)
