| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2015-02-04 |
| タイトル |
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タイトル |
<Originals> COX-2 expression and the prevalence of regulatory T cells in tumor and non-tumor sites of hepatocellular carcinoma |
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言語 |
en |
| 著者 |
Nakata, Yasuyuki
Takeyama, Yoshifumi
Haji, Seiji
Araki, Mariko
Yasuda, Takeo
Nakai, Takuya
Okuno, Kiyotaka
Shiozaki, Hitoshi
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| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
hepatocellular carcinoma, COX-2, FOXP3, immunostaining |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| 著者 所属 |
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|
値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者 所属 |
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値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者 所属 |
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値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者 所属 |
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値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者 所属 |
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値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者 所属 |
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値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者 所属 |
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値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者 所属 |
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値 |
Department of Surgery, Kinki University Faculuty of Medicine |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 著者所属(翻訳) |
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値 |
Kinki University |
| 版 |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
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出版者 |
Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 37,
号 2,
p. 81-90,
発行日 2012-12-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03866092 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
[Abstract] Aim : The expression of cyclooxygenase-2 (COX-2) plays a role in the differentiation and guidance of regulatory T cells (FOXP3^+ Tregs), and this mechanism has also been studied extensively in hepatocellular carcinoma (HCC). In this study, we investigated the expression of COX-2 and prevalence of FOXP3^+ Tregs in tumor and non-tumor sites to elucidate their association with the clinicopathological features of HCC and disease outcome. Method : This study involved 44 patients with HCC who had undergone hepatectomy without any preoperative treatment. Paraffin-embeddednodules (n=44) were sectioned for immunostaining with COX-2 and FOXP3 monoclonal antibodies, and the degree of COX-2 expression and prevalence of FOXP3^+ Tregs were measured. Results : COX-2 expression in the non-tumor sites showed a positive correlation with the number of FOXP3^+ Tregs (p < 0.001). In addition, in the non-tumor sites, the high FOXP3^+ Tregs prevalence group was significantly associated with TNM stages (p=0.003) and AFP (p=0.027). The expression of COX-2 in the nontumor sites was also significantly associated with disease-free survival (p=0.005). Conclusion : The present findings suggest the association of COX-2 expression in the nontumor sites with disease-free survival and thus the recurrence of HCC. In addition, COX-2 expression and the prevalence of FOXP3^+ Tregs have been positively correlated in the non-tumor sites, indicating that their interaction influences the outcome of HCC. To prevent the recurrence of HCC, it may be necessary to inhibit the expression of COX-2. |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
AA0050842X-20121200-0081.pdf (13.2 MB)
