{"created":"2023-06-20T16:40:20.253025+00:00","id":10577,"links":{},"metadata":{"_buckets":{"deposit":"52dd3bc7-02b8-48a0-adf1-662d7935ae07"},"_deposit":{"created_by":3,"id":"10577","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10577"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00010577","sets":["14:923:1519:1525","21:3039:3477:3488"]},"author_link":["20624"],"item_4_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2014-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"10","bibliographicPageStart":"1","bibliographicVolumeNumber":"39","bibliographic_titles":[{},{"bibliographic_title":"ACTA MEDICA KINKI UNIVERSITY","bibliographic_titleLang":"en"}]}]},"item_4_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"[Abstract] Post-translational modifications of histones are important regulatory mechanisms of numerous biological processes such as gene transcription, DNA damage response, hormonal responses, and metabolism. Recent growing evidence indicates that dysregulation of these modifications has strong impact on onset and progression of human diseases including cancer, immune disorder, and obesity. Here we summarize regulatory mechanisms of histone lysine methylation with special emphasis on how the homeostasis of histone methylations are regulated and how deregulated demethylation process contributes to the pathological conditions. Since epigenetics is tightly linked to numerous biological phenomena, further understanding of regulatory mechanisms underlying epigenetic alterations may identify novel therapeutic intervention of human diseases and, eventually, lead to personalized medicine.","subitem_description_type":"Abstract"}]},"item_4_description_37":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"Article","subitem_description_type":"Other"}]},"item_4_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_4_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"Kinki University Medical Association"}]},"item_4_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866092","subitem_source_identifier_type":"ISSN"}]},"item_4_text_8":{"attribute_name":"著者 所属","attribute_value_mlt":[{"subitem_text_value":"Department of Biochemistry, Kinki University Faculty of Medicine"}]},"item_4_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Kinki University"}]},"item_4_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Okada, Hitoshi"},{"creatorName":"オカダ, ヒトシ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"20624","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AA0050842X-20140600-0001.pdf","filesize":[{"value":"8.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA0050842X-20140600-0001.pdf","url":"https://kindai.repo.nii.ac.jp/record/10577/files/AA0050842X-20140600-0001.pdf"},"version_id":"ded72075-3140-45d5-b0fd-bdd266547b95"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"epigenetics","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histone lysine demethylase(KDM)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"histone methyltransferase(HMT)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"KDM4/JMJD2 family of proteins","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Jumonji C(JmjC)domain","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"alpha-ketoglutarate(α-KG)","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"2-hydroxyglutarate(2-HG)","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"<Review> Histone Lysine Demethylase and Human Diseases","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"<Review> Histone Lysine Demethylase and Human Diseases","subitem_title_language":"en"}]},"item_type_id":"4","owner":"3","path":["1525","3488"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-17"},"publish_date":"2014-08-17","publish_status":"0","recid":"10577","relation_version_is_last":true,"title":["<Review> Histone Lysine Demethylase and Human Diseases"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T18:47:35.376751+00:00"}