| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2013-09-16 |
| タイトル |
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タイトル |
<Originals> The effect of sevoflurane or propofol with or without an anti-emetic dose of droperidol on the QTc interval and the transmural dispersion of repolarization |
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言語 |
en |
| 著者 |
Kajikawa, Ryuji
Kamamoto, Hiromichi
Shiba, Mayuka
Uchida, Tomohisa
Shirai, Toru
Hiramatsu, Kenji
Futagawa, Koichi
Nakao, Shinichi
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| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
QTc interval, Tp-e interval, sevoflurane, droperidol, propofol |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
departmental bulletin paper |
| 著者 所属 |
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値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anesthesiology, Nara Hospital Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学奈良病院 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 版 |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
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出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 38,
号 1,
p. 25-31,
発行日 2013-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
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収録物識別子 |
03866092 |
| 抄録 |
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内容記述タイプ |
Abstract |
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内容記述 |
[Abstract] Purpose : Sevoflurane and droperidol but not propofol induce QTc interval prolongation, but there are several conflicting reports. We investigated the effects of sevoflurane and propofol with or without an anti-emetic dose of droperidol on the QTc interval and the transmural dispersion of repolarization for 2 hours, and the QT interval was adjusted for the patient's heart rate using 3 formulae. Methods : One hundred two American Society of Anesthesiologists (ASA) physical status I-II patients, aged 20-70, were randomly allocated to one of four groups : Group 1 (n＝25) receiving sevoflurane anesthesia without droperidol (1.25 mg), Group 2 (n＝26) receiving sevoflurane anesthesia with droperidol, Group 3 (n＝ 25) receiving propofol anesthesia without droperidol, or Group 4 (n＝26) receiving propofol anesthesia with droperidol. RR intervals, QT intervals, and Tp-e intervals, which indicates the dispersion of ventricular repolarization (TDR), were mea-sured. The QT interval was adjusted for the patient's heart rate using the formulae of Bazett, Fridericia, and Matsunaga. Results : Sevoflurane significantly prolonged the QTc, but droperidol did not enhance sevoflurane- induced QTc prolongation in all the formulae. Conversely, propofol did not affect the QTc in all formulae. Tp-e intervals were not affected in any of the groups. Conclusion : Although it significantly prolongs the QTc interval, sevoflurane, even with droperidol, does not seem to cause lethal arrhythmias associated with QT prolongation, because it does not induce Tp-e prolongation. Propofol is safer than sevoflurane in terms of arrhythmias associated with QT interval prolongation. Bazett's formula is reliable for detecting anesthetic- induced QT prolongation. |
| フォーマット |
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内容記述タイプ |
Other |
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内容記述 |
application/pdf |
AA0050842X-20130600-0025.pdf (1.2 MB)
