| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2012-06-28 |
| タイトル |
|
|
タイトル |
<Originals> Application of layer-specific markers in the evaluation of abnormal cytoarchitecture in the olfactory bulb of prokineticin receptor 2 deficient mice |
|
言語 |
en |
| 著者 |
Yamazaki, Chihiro
Nagano, Mamoru
Sujino, Mitsugu
Kubo, Atsuko
Terashima, Toshio
Ozawa, Hitoshi
Shigeyoshi, Yasufumi
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
olfactory bulb, prokineticin, tyrosine hydroxylase, parvalbumin, reelin |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 所属 |
|
|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Division of Anatomy and Developmental Neurobiology, Department of Cell Biology and Physiology, Kobe University Graduate School of Medicine |
| 著者 所属 |
|
|
値 |
Department of Anatomy and Neurobiology, Nippon Medical School |
| 著者 所属 |
|
|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
神戸大学大学院医学研究科 |
| 著者所属(翻訳) |
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|
値 |
日本医科大学 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 版 |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
|
|
出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 37,
号 1,
p. 35-43,
発行日 2012-06-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Prokineticin receptor 2 gene mutant mice (Pkr2^<-1->) show deformity in the olfactory bulb (OB), they lose axonal invasion from the olfactory sensory neurons and olfactory interneurons fail to migrate in the OB. In the present study, we examined whether the mutant has an abnormality in the laminar structure in the OB by HE staining and immunohistochemistry using antityrosine hydroxylase (TH), parvalbumin (PV), and reelin (RE) with special reference to the layered structure. In Pkr2^<-1-> mice, TH-immunoreactive neurons were localized in the marginal area of the OB and the number and size of TH-expressing cells were markedly decreased. The distribution of PV-immunoreactive cells showed no apparent difference but the cells were significantly smaller in the mutant is wild-type mice (WT). RE-immunoreactive mitral cells showed abnormal alignment, the direction of neurite outgrowth was not well coordinated and they were much smaller than those in WT mice. The present findings suggest that not only the impairment of neuronal migration but also the loss of afferent axonal projection from the olfactory epithelium to the OB arrested the maturation and induced apoptosis of PV-, TH-, and RE-immunoreactive neurons in Pkr2^<-1->. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20120600-0035.pdf (2.3 MB)
