| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2012-06-28 |
| タイトル |
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|
タイトル |
<Originals> Profile of tyrosine hydroxylase-expressing neurons in the olfactory bulb of prokineticin type 2 receptor-deficient mice during embryonic development |
|
言語 |
en |
| 著者 |
Kubo, Atsuko
Nagano, Mamoru
Sujino, Mitsugu
Masumoto, Kohei
Yamazaki, Chihiro
Terashima, Toshio
Shigeyoshi, Yasufumi
|
| 言語 |
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言語 |
eng |
| キーワード |
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主題 |
olfactory bulb, tyrosine hydroxylase, prokineticin, periglomerular cell, embryo, dopamine, tufted cell |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 所属 |
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|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者 所属 |
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値 |
Division of Anatomy and Developmental Neurobiology, Department of Cell Physiology, Kobe University Graduate School of Medicine |
| 著者 所属 |
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|
値 |
Department of Anatomy and Neurobiology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 著者所属(翻訳) |
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値 |
神戸大学大学院医学研究科 |
| 著者所属(翻訳) |
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値 |
近畿大学医学部 |
| 版 |
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出版タイプ |
VoR |
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出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
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出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 37,
号 1,
p. 25-33,
発行日 2012-06-01
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| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Dopamine neurons in the olfactory bulb play essential roles in the maintenance of olfactory function. The maturation of these neurons involves mitosis, cell migration and the transcriptional regulation of specific neurotransmitters and is an intensively studied process. In our present study, we investigated the embryonic development of tyrosine-hydroxylase (TH)-expressing neurons in the main olfactory bulb (MOB) of Pkr2^<-1-> mice that lack axonal infiltration from the olfactory neurons (ON) and wild-type littermates (WT) at E16.5, E18.5 and P0 using immunohistochemical techniques. Even at E16.5, we observed two populations of neurons in the MOB of WT mice, one scattered in the primitive glomerular layer and another population of TH-positive neurons in the surface region of the primitive granular cell layer. The number of TH-positive neurons had increased markedly by P0. Pkr2^<-1-> mouse embryos and neonates showed disorganization of the layered structure, mainly due to the loss of glomerular layer in the olfactory system. The number of TH-immunoreactive cells per slice was markedly lower at P0 but not at E16.5 and E18.5. Interestingly, even in Pkr2^<-1-> mice, TH-immunoreactive neurons were still present in the periphery of the MOB. Hence, it is highly probable that the lack of Pkr2-i- does not affect the migration of TH-containing neurons from the subventricular zone to the periphery of the MOB during embryonic development but strongly impairs the migration of TH-expressing neurons or TH expression in the MOB around birth. |
| 内容記述 |
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内容記述タイプ |
Other |
|
内容記述 |
Masumoto, Koh-hei |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20120600-0025.pdf (3.3 MB)
