| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2012-06-28 |
| タイトル |
|
|
タイトル |
<Originals> The expression of human epidermal growth factor receptor 2 in peritoneal metastasis of gastric cancer |
|
言語 |
en |
| 著者 |
Imamoto, Haruhiko
Imano, Motohiro
Sato, Takao
Ito, Tatsuki
Okuno, Kiyotaka
Shiozaki, Hitoshi
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
gastric cancer, peritoneal metastasis, human epidermal growth factor receptor 2 |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 所属 |
|
|
値 |
Department of Surgery, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Surgery, Kinki University Faculty of Medicine: Ambulatory Treatment Center, Kinki University Hospital |
| 著者 所属 |
|
|
値 |
Department of Pathology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Pathology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Surgery, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Surgery, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部: 近畿大学病院 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 版 |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
|
|
出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 37,
号 1,
p. 19-23,
発行日 2012-06-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] (Background) The prognosis of gastric cancer patients with peritoneal metastasis (PM) is very poor. In recent report suggested that a monoclonal antibody that targets human epidermal growth factor receptor 2 (HER2) improve the prognosis of gastric cancer with HER2 overexpression and/or gene amplification. However, HER2 overexpression and/or gene amplification of gastric patients with PM is unclear. (Methods) HER2 expression of primary gastric lesion and peritoneal metastasis was investigated immunohistologically and by fluorescence in-situ hybridization. Specimens were obtained from 15 patients with gastric cancer. (Results) There was no difference about the results of HER2 overexpression and gene amplification between primary gastric lesion and peritoneal metastasis. Fifteen gastric carcinoma tissue samples were classified as follows: 12 (80％) were scored as 0, 1 (6.7％) as 1, 2 (13.3％) as 2, and 0 (0％) as 3. Two specimens 2+ for HER-2 expression with immunohistological staining were analyzed by fluorescence in-situ hybridization. HER-2 gene amplification was not determined in these samples. (Conclusion) Primary gastric lesion and peritoneal metastasis of gastric cancer did not show HER2 amplification and/or overexpression. Further, prospective, larger-scale studies are needed to evaluate the efficacy of monoclonal antibody that targets HER2 to GC patients with PM. |
| 内容記述 |
|
|
内容記述タイプ |
Other |
|
内容記述 |
Satou, Takao, Itoh, Tatsuki |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20120600-0019.pdf (931.2 kB)
