| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2012-06-28 |
| タイトル |
|
|
タイトル |
<Originals> Antimicrobials for the treatment of febrile neutropenia clinical usefulness of antimicrobial cycling |
|
言語 |
en |
| 著者 |
Tatsumi, Yoichi
Kanamaru, Akihisa
Matsumura, Itaru
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
antimicrobial cycling, gram-negative bacteria, methicillin-resistant Staphylococcus aureus (MRSA), febrile neutropenia |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者 所属 |
|
|
値 |
Department of Hematology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Hematology, Kinki University Faculty of Medicine |
| 著者 所属 |
|
|
値 |
Department of Hematology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 著者所属(翻訳) |
|
|
値 |
近畿大学医学部 |
| 版 |
|
|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
|
|
出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 37,
号 1,
p. 9-18,
発行日 2012-06-01
|
| ISSN |
|
|
収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Bacterial or fungal sepsis is one of the leading causes of death in patients with hematological disease. Neutropenia occurs depending on the dose of chemotherapy or radiotherapy and is considered to be an important predictive factor for the incidence and severity of infection in chemotherapy patients. Approximately 40％ to 60％ of febrile patients who receive chemotherapy are clinically or microbiologically diagnosed with infection, while the remaining patients are diagnosed with fever of unknown origin and treated as such. Along with the routine use of carbapenem antibiotics (which mainly target Gram-negative bacteria) in recent years, multidrug-resistant bacteria, including methicillin-resistant Staphylococcus aureus (MRSA), have evolved and have become a serious clinical and social problem, however, no specific strategy for infection control has yet been established. For patients with hematological disease who had fever caused by an unknown pathogen, including febrile neutropenic patients, we performed antimicrobial cycling and assessed changes over time in the isolation rates of MRSA, Pseudomonas aeruginosa, etc. For 448 patients admitted to our hospital, the use of carbapenem, penicillin, fluoroquinolone, and cephem antibiotics (all of which were injectable preparations) was rotated in this order at 3-month intervals over a two-year period (antimicrobial cycling). We concluded that cycling of the four classes of antibiotics used in this study was effective in patients with fever of unknown origin, including febrile neutropenic (FN) patients, since it could decrease the isolation rates of MRSA and P. aeruginosa. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20120600-0009.pdf (893.6 kB)
