| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2011-08-22 |
| タイトル |
|
|
タイトル |
<Originals> Gabapentin produces antinociceptive effects on the spinal cord with simultaneous activation of descending facilitation in spinal nerve-ligated rats |
|
言語 |
en |
| 著者 |
Yabuta, Koichi
Takasugi, Yoshihiro
Tabuchi, Masaki
Mizuguchi, Nobuyuki
Koga, Yoshihisa
Higashino, Hideaki
Nakao, Shinichi
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
gabapentin, descending pathway, spinal, tail-flick test, rat |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者所属(翻訳) |
|
|
値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Pharmacology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Life Science Research Institute, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Pharmacology, Kinki University Faculty of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Department of Anesthesiology, Kinki University Faculty of Medicine |
| 版 |
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出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 名前 |
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出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 36,
号 1,
p. 7-14,
発行日 2011-06-01
|
| ISSN |
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
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内容記述タイプ |
Abstract |
|
内容記述 |
[Abstract] Gabapentin has been proposed as one of several first-line agents to treat neuropathic pain. Although both spinal and supraspinal neuronal mechanisms participate in the antinociceptive effects of gabapentin, the supraspinal contribution to the effects of gabapentin at the spinal level remains unclear. We evaluated the role of descending modulation in the antinociceptive effects of gabapentin at the spinal level using continuous blockade ofdescending pathways in spinal nerve-ligated (SNL) rats. Tail flick (TF) latencies following sham operation or SNL operation were measured for 2 weeks. Rats were chronically implanted with both cervical and lumber intrathecal catheters, and a continuous cervical intrathecal infusion of 1% lidocaine was utilized for suppression of descending modulation. TF latencies following intrathecal administration of normal saline or 50μg gabapentin were measuredwith/without descending modulation in SNL and sham-operated rats. TF latencies (percentage of the maximum possible effect) were significantly shortened in the 2 weeks following SNL operation. With descending modulation, intrathecal gabapentin did not prolong TF latencies in sham-operated rats, and prolonged TF latency only at the 60-min time point in SNL rats ; 28.9± 17.3％ (p＜0.05 compared with baseline). Without descending modulation, intrathecal gabapentin to shamoperated rats slightly prolonged TF latencies at 15 and 30 min compared with the saline group of sham-operated rats, but intrathecal gabapentin to SNL rats resulted in significant prolongation of TF latencies ; 41.6+39.0％ (p＜0.01) to 68.2+ 37.4％ (p＜0.001). The results of this study indicate that gabapentin causes both apparent antinociception at the spinal level and simultaneousdescending facilitation in neuropathic pain conditions. |
| フォーマット |
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内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20110600-0007.pdf (3.7 MB)
