| Item type |
☆紀要論文 / Departmental Bulletin Paper(1) |
| 公開日 |
2010-07-06 |
| タイトル |
|
|
タイトル |
Hypersensitivity caused by suppression of descending inhibitory pathways following lumbar intrathecal injection of lidocaine in rats |
|
言語 |
en |
| 著者 |
Fuyuta, Masaki
Takasugi, Yoshihiro
Tabuchi, Masaki
Higashino, Hideaki
Koga, Yoshihisa
|
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
hypersensitivity, tail flick reflex, lidocaine, descending inhibitory pathway, C-polymodal nociceptor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
departmental bulletin paper |
| 著者所属(翻訳) |
|
|
値 |
Departments of Anesthesiology, Kinki University School of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Departments of Anesthesiology, Kinki University School of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Departments of Pharmacology, Kinki University School of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Departments of Pharmacology, Kinki University School of Medicine |
| 著者所属(翻訳) |
|
|
値 |
Departments of Anesthesiology, Kinki University School of Medicine |
| 版 |
|
|
出版タイプ |
NA |
|
出版タイプResource |
http://purl.org/coar/version/c_be7fb7dd8ff6fe43 |
| 出版者 名前 |
|
|
出版者 |
The Kinki University Medical Association |
| 書誌情報 |
en : ACTA MEDICA KINKI UNIVERSITY
巻 33,
号 1/2,
p. 47-54,
発行日 2008-12-01
|
| ISSN |
|
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収録物識別子タイプ |
ISSN |
|
収録物識別子 |
03866092 |
| 抄録 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Although the etiology of neural blockrelated transient neurological sequelae following spinal anesthesia, such as transient neurological symptoms (TNS) and less serious sensory disturbances, is still unclear, previous reports have described the facilitation of ascending nociceptive pathways as the source of complications resulting from local anesthetic toxicity, needle trauma, and patient positioning. We hypothesized that, in addition to the facilitation of ascending nociceptive pathways, the intrathecal injection of local anesthetics might interrupt descending inhibitory pathways, leading to hypersensitivity. To test this hypothesis, changes in tail flick (TF) latency were evaluated under lidocaine blockade of descending inhibitory pathways at the thoracic spinal cord level and under lumbar intrathecal lidocaine injection in rats. Furthermore, the effects of lumbar intrathecal lidocaine injection on cerebrospinal fluid (CSF) concentrations of neurotransmitters related to nociceptive transmission were investigated. The results revealed that thoracic intrathecal lidocaine shortened TF latency immediately after injection, while lumbar intrathecal lidocaine injection initially prolonged TF latency to the cut-off point and subsequently reduced TF latency compared to the baseline. Lumbar intrathecal lidocaine caused a significant reduction in norepinephrine concentrations in the CSF. These results indicate that the reduction of TF latency following lumbar intrathecal lidocaine injection was caused by the suppression of nor adrenergic descending inhibitory pathways. We concluded that the enhanced activity of dorsal horn neurons due to the suppression of descending inhibitory pathways by intrathecal lidocaine injection is one of the possible mechanisms of transient neurological sequelae. |
| フォーマット |
|
|
内容記述タイプ |
Other |
|
内容記述 |
application/pdf |
AA0050842X-20081200-0047.pdf (516.1 kB)
