{"created":"2023-06-20T16:40:16.630527+00:00","id":10494,"links":{},"metadata":{"_buckets":{"deposit":"06300710-610f-4b4d-8475-b8bea5811d8e"},"_deposit":{"created_by":3,"id":"10494","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"10494"},"status":"published"},"_oai":{"id":"oai:kindai.repo.nii.ac.jp:00010494","sets":["14:923:1519:1545","21:3039:3477:3479"]},"author_link":["20258","20259"],"item_2_biblio_info_21":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2009-06-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"25","bibliographicPageStart":"15","bibliographicVolumeNumber":"34","bibliographic_titles":[{},{"bibliographic_title":"ACTA MEDICA KINKI UNIVERSITY","bibliographic_titleLang":"en"}]}]},"item_2_description_33":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Psoriasis is an important inflammatory disease in the dermatological field. It is characterized with erythematous plaque with thick scales clinically and epidermal thickening and perivascular lymphocyte infiltration histopathologically. Although pathogenesis of psoriasis has not been elucidated fully, abnormalities both in T-cell mediated immunity and keratinization have been addressed. Various cytokines, chemokines, angiogenic factors released from epidermal keratinocytes may affect the innate and acquired immune systems. Interferon α, tumor necrosis factor α(TNF α), interleukin-2 (IL-2), IL-12 and IL-23 have been revealed to be key factors in pathogenesis of psoriasis, a Thl-dominant disease. Then, new biologic drugs targeting these cytokines have been developed recently as T-cell agents, anti-TNF agents and anti-IL-12 and IL-23 agents. This comprehensive review focuses recent findings in pathophysiology of psoriasis and development of new therapeutic modalities with special reference to novel biologics.","subitem_description_type":"Abstract"}]},"item_2_description_41":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_2_publisher_14":{"attribute_name":"出版者 名前","attribute_value_mlt":[{"subitem_publisher":"The Kinki University Medical Association"}]},"item_2_source_id_22":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03866092","subitem_source_identifier_type":"ISSN"}]},"item_2_text_9":{"attribute_name":"著者所属(翻訳)","attribute_value_mlt":[{"subitem_text_value":"Department of Dermatology, Kinki University School of Medicine"},{"subitem_text_value":"Department of Dermatology, Kinki University School of Medicine"}]},"item_2_version_type_12":{"attribute_name":"版","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_be7fb7dd8ff6fe43","subitem_version_type":"NA"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kawara, Shigeru"},{"creatorName":"カワラ, シゲル","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"20258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawada, Akira"},{"creatorName":"カワダ, アキラ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"20259","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-18"}],"displaytype":"detail","filename":"AA0050842X-20090600-0015.pdf","filesize":[{"value":"2.7 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"AA0050842X-20090600-0015.pdf","url":"https://kindai.repo.nii.ac.jp/record/10494/files/AA0050842X-20090600-0015.pdf"},"version_id":"e9d3191f-8cbc-4f19-a38f-51c262a6da40"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"psoriasis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"pathophysiology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"therapy","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"biologics","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Recent advances in psoriasis with special reference to pathophysiology and therapeutics","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Recent advances in psoriasis with special reference to pathophysiology and therapeutics","subitem_title_language":"en"}]},"item_type_id":"2","owner":"3","path":["1545","3479"],"pubdate":{"attribute_name":"公開日","attribute_value":"2010-06-09"},"publish_date":"2010-06-09","publish_status":"0","recid":"10494","relation_version_is_last":true,"title":["Recent advances in psoriasis with special reference to pathophysiology and therapeutics"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-06-20T18:49:48.433363+00:00"}